37132-61-9

Basic information

• Product Name: N,N'-Bis<2-(3,4-dimethoxyphenyl)ethyl>-1,2,4-triazine-3,5-diamine
• CAS NO: 37132-61-9
• Molecular Weight: 439.514
• Mol File: 37132-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N'-Bis<2-(3,4-dimethoxyphenyl)ethyl>-1,2,4-triazine-3,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Bis<2-(3,4-dimethoxyphenyl)ethyl>-1,2,4-triazine-3,5-diamine(37132-61-9)
• EPA Substance Registry System: N,N'-Bis<2-(3,4-dimethoxyphenyl)ethyl>-1,2,4-triazine-3,5-diamine(37132-61-9)

Safety Data

• Hazardous Substances Data: 37132-61-9(Hazardous Substances Data)

Upstream product

• 626-08-4 6-aza-2-thiouracil 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Relevant articles and documents

Amination, III. Trimethylsilanol as Leaving Group, V. Silylation - Amination of Hydroxy N-Heterocycles

Hydroxy N-heterocycles such as 18, 21, 26, and others are efficiently aminated in a one-step/one-pot procedure by silylation-amination to give 20, 23 - 25 etc.Silylation converts aromatic hydroxy N-heterocycles into activated and lipophilic intermediates of type 3, 8 which react in situ with ammonia, primary or secondary amines to form the corresponding mono-, bis- or tris-aminated products (5, 10).This addition-elimination of amines to O-silylated heterocycles is Lewis acid-catalysed and proceeds usually in high yields if the leaving group trimethylsilanol is converted in situ by excess silylated agent into hexamethyldisiloxane.Scope and limitations of this simple procedure are discussed.