37134-40-0 Usage
Description
BicozaMycin benzoate, FR 2054 is a polar metabolite derived from Streptomyces sapporonensis, first isolated in 1972. It exhibits activity against Gram-negative bacteria and is characterized by its selective Gram-negative profile, which is uncommon among Streptomyces metabolites. To improve its in vivo absorption, the benzoate ester was synthesized by reacting it with the more exposed primary alcohol.
Uses
Used in Veterinary Medicine:
BicozaMycin benzoate, FR 2054 is used as a veterinary antibiotic for the treatment of bacterial infections in animals. Its selective activity against Gram-negative bacteria makes it a valuable addition to the arsenal of antibiotics used in veterinary medicine, particularly for infections that are resistant to other commonly used antibiotics.
Used in Pharmaceutical Research:
Due to its unique properties and activity against Gram-negative bacteria, BicozaMycin benzoate, FR 2054 may also be used as a starting point for pharmaceutical research and development. Scientists can explore its potential for the creation of new antibiotics or the modification of existing ones to combat antibiotic-resistant bacteria.
Biological Activity
bicyclomycin benzoate is a novel antibiotic produced by s. sapporonensi [1]. bicyclomycin shows an inhibitory effect on gram-negative bacteria, such as e. coli, klebsiella, shigella, salmonella, citrobacter, e. cloacae, and the pathogenic group of neisseria [2]. bicyclomycin benzoate is inactive against proteus, p. aeruginosa, and gram-positive bacteria [1,2].
in vitro
the mig of bicyclomycin for e.coli nihj jc-2 was 25-50 μg/ml. bicyclomycin (25-50 μg/ml) completely inhibited formation of visible colonies or turbidity of this organism on agar plates, in nutrient broth, and in heart infusion broth [2]. bicyclomycin inhibited atpase activity in the presence of poly(dc) and ribo(c)10. the approximate ic50 value for inhibition of transcription termination at rho-dependent sites was 5 μm. the inhibitory effect of bicyclomycin on rho-dependent transcripts was accompanied by the appearance of a new set of transcripts. in the presence of poly(dc), bicyclomycin reversibly inhibited the ribo(c)10-stimulated atpase activity. the extrapolated ki for bicyclomycin was 2.8 μm without ribo(c)10, which was increased to 26 μm in the presence of ribo(c)10 [3].
in vivo
bicyclomycin showed therapeutic activity for infections with several strains of e. coli which were resistant to the control antibiotics. the ed50 of bicyclomycin for infection with gp-resistant e.coli 312 was 3.05 (1.47-7.66) mg/mouse [2].
references
[1] miyoshi, t. ,miyairi, n.,aoki, h., et al. bicyclomycin, a new antibiotic. i. taxonomy, isolation and characterization. j.antibiot.(tokyo) 25(10), 569-575(1972).[2] nishida, m. ,mine, y.,matsubara, t., et al. bicyclomycin, a new antibiotic. iii. in vitro and in vivo antimicrobial activity. j.antibiot.(tokyo) 25(10), 582-593(1972).[3] magyar a, zhang x, kohn h, et al. the antibiotic bicyclomycin affects the secondary rna binding site of escherichia coli transcription termination factor rho[j]. journal of biological chemistry, 1996, 271(41): 25369-25374.
Check Digit Verification of cas no
The CAS Registry Mumber 37134-40-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,1,3 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37134-40:
(7*3)+(6*7)+(5*1)+(4*3)+(3*4)+(2*4)+(1*0)=100
100 % 10 = 0
So 37134-40-0 is a valid CAS Registry Number.
