37162-46-2

Basic information

• Product Name: 2H-1,2,4-BENZOTHIADIAZINE, 7-BROMO, 1,1-DIOXIDE
• Synonyms: 2H-1,2,4-BENZOTHIADIAZINE, 7-BROMO, 1,1-DIOXIDE
• CAS NO: 37162-46-2
• Molecular Formula: C7H5BrN2O2S
• Molecular Weight: 261.1
• Mol File: 37162-46-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-1,2,4-BENZOTHIADIAZINE, 7-BROMO, 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,2,4-BENZOTHIADIAZINE, 7-BROMO, 1,1-DIOXIDE(37162-46-2)
• EPA Substance Registry System: 2H-1,2,4-BENZOTHIADIAZINE, 7-BROMO, 1,1-DIOXIDE(37162-46-2)

Safety Data

• Hazardous Substances Data: 37162-46-2(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 54734-84-8 2-amino-5-bromobenzenesulfonamide 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 124-38-9 carbon dioxide 
• 359-85-3 4H-benzo[e][1,2,4]thiadiazine-1,1-dioxide 
• 122-51-0 orthoformic acid triethyl ester 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 5455-59-4 2-Nitrobenzenesulfonamide 

Relevant articles and documents

Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as potentiators of AMPA receptors. Attention was paid to the impact of the substituent introduced at the 7-position of the heterocycle. The biological evalu

Acetic acid derivatives of 3,4-dihydro-2 H-1,2,4-benzothiadiazine 1,1-dioxide as a novel class of potent aldose reductase inhibitors

A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group and a N4-acetic acid group on the benzothiadiazine, were found to be potent and selective aldose reductase inhibitors in vitro with IC50 values ranging from 0.032 to 0.975 μM. 9m proved to be the most active in vitro. The eight top-scoring compounds coming from the in vitro test for ALR2 inhibition activity were then tested in vivo, whereby three derivatives, 9i, 9j, and 9m, demonstrated a significantly preventive effect on sorbitol accumulation in the sciatic nerve in the 5-day streptozotocin-induced diabetic rats in vivo. Structure-activity relationship and molecular docking studies highlighted the importance of substitution features of N4-acetic acid group and halogen-substituted N2-benzyl group in the benzothiadiazine scaffold and indicated that substitution with hallogen at C-7 had a remarkably strong effect on ALR2 inhibition potency.

Iodinated derivatives of 2 aminobenzenesulfonamide and 1,2,4 benzothiadiazine 1,1 dioxide

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