371765-85-4

Basic information

• Product Name: 2-bromo-4-(((4-fluoro-3-(trifluoromethyl)benzyl)oxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile
• CAS NO: 371765-85-4
• Molecular Weight: 468.248
• Mol File: 371765-85-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-4-(((4-fluoro-3-(trifluoromethyl)benzyl)oxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-(((4-fluoro-3-(trifluoromethyl)benzyl)oxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile(371765-85-4)
• EPA Substance Registry System: 2-bromo-4-(((4-fluoro-3-(trifluoromethyl)benzyl)oxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile(371765-85-4)

Safety Data

• Hazardous Substances Data: 371765-85-4(Hazardous Substances Data)

Upstream product

• 362527-61-5 ethyl 3-bromo-4-cyanobenzoate 
• 7149-03-3 ethyl 3-bromo-4-aminobenzoate 
• 89891-70-3 2-bromo-4-formylbenzonitrile 
• 371765-79-6 2-bromo-4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 
• 184970-26-1 4-fluoro-3-trifluoromethylbenzyl bromide 
• 94-09-7 p-aminoethylbenzoate 

Relevant articles and documents

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

A non-methionine FT inhibitor lead structure (1) was designed through computer modeling of the peptidomimetic FT inhibitor ABT839. Optimization of this lead resulted in compounds 2e and 2g, with FT IC50 values of 1.3 and 1.8 nM, GGT IC50 of 1400 nM, and EC50 (Ras processing) values of 13 and 11 nM, respectively.