371979-21-4

Basic information

• Product Name: (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-hydroxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
• CAS NO: 371979-21-4
• Molecular Weight: 408.452
• Mol File: 371979-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-hydroxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-hydroxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(371979-21-4)
• EPA Substance Registry System: (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-hydroxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(371979-21-4)

Safety Data

• Hazardous Substances Data: 371979-21-4(Hazardous Substances Data)

Upstream product

• 238753-26-9 (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 35421-08-0 4-hydroxybenzyl chloride 
• 238753-27-0 (2R,4R)-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

The chemical synthesis of a series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid [(2R,4R)-APDC] as constrained analogues of γ-substituted glutamic acids is described. Appropriate substitution of the N1-position results in agonist, partial agonist, or antagonist activity at mGluR2, mGluR3, and/or mGluR6.