37239-47-7

Basic information

• Product Name: WILFORGINE
• Synonyms: WILFORGINE;Aids088959;Aids-088959;(8alpha)-8-(Acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)- evonimine Wilforgin;3-Furancarboxylic acid (8R,9R,10R,11S,12R,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-21-hydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-yl ester;4-27-00-06847 (Beilstein Handbook Reference);3-Furancarboxylic acid (8R,9R,10R,11S,12R,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-;3-Furancarboxylic acid, 10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-21-hydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-yl ester, (8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-
• CAS NO: 37239-47-7
• Molecular Formula: C41H47NO19
• Molecular Weight: 857.81
• Product Categories: reagent;standard substance;CR
• Mol File: 37239-47-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 211℃
• Boiling Point: 859.9 °C at 760 mmHg
• Flash Point: 473.8 °C
• Appearance: /
• Density: 1.43
• PKA: 11.59±0.70(Predicted)
• CAS DataBase Reference: WILFORGINE(CAS DataBase Reference)
• NIST Chemistry Reference: WILFORGINE(37239-47-7)
• EPA Substance Registry System: WILFORGINE(37239-47-7)

Safety Data

• Hazardous Substances Data: 37239-47-7(Hazardous Substances Data)

Usage

Description

Wilforgine, a dihydroagarofuran sesquiterpenoid and pyridine alkaloid with the chemical formula C41H47NO19, is an alkaloid derived from Tripterygium wilfordii Hook. It forms colorless plates from MeOH-Me2CO and is dextrorotatory with a specific rotation of [α]25/sup>D + 25° (Me2CO). Wilforgine is known for its lymphocyte immunosuppressive properties, as well as its anti-tumor and anti-inflammatory effects.

Uses

Used in Pharmaceutical Industry:
Wilforgine is used as a lymphocyte immunosuppressant for its anti-tumor and anti-inflammatory effects. It helps in modulating the immune system and has potential applications in the treatment of various cancers and inflammatory diseases.
Used in Research and Development:
Wilforgine is used for content determination, identification, and pharmacological experiments in the field of drug discovery and development. Its unique properties make it a valuable compound for studying its potential therapeutic effects and understanding its mechanisms of action.
Used in Traditional Medicine:
Wilforgine, being derived from Tripterygium wilfordii, has a history of use in traditional medicine. It is employed for its immunosuppressive, anti-tumor, and anti-inflammatory properties, which can be beneficial in the treatment of various ailments and conditions.

Biological activity

Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.

References

Beroza., J. Arner. Chern. Soc., 74, 1585 (1952) Beroza., ibid, 75,44 (1953)