372504-89-7Relevant articles and documents
A new, ring closing metathesis-based synthesis of (-)-fumagillol
Boiteau, Jean-Guy,Van De Weghe, Pierre,Eustache, Jacques
, p. 2737 - 2740 (2001)
(Equation presented) A new strategy to access the fumagillin/fumagillol skeleton is proposed. An Evans aldolization and a RCM involving an enone are used for the preparation of a key cyclohexanone intermediate, which was readily converted to fumagillol. The synthesis also features an efficient preparation of isogeraniol and isogeranic acid.
GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 112-113, (2010/02/07)
The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.