372941-48-5 Usage
Description
1-(4-Fluorophenyl)-1,3-dihydro-3-oxo-5-isobenzofurancarbonitrile is an off-white solid that serves as an intermediate in the chemical synthesis process. It is a compound with a specific molecular structure that is utilized in the pharmaceutical industry for the preparation of certain medications.
Uses
Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-1,3-dihydro-3-oxo-5-isobenzofurancarbonitrile is used as an intermediate for the preparation of Citalopram, a widely prescribed antidepressant medication. Its role in the synthesis process is crucial for the production of the final drug product, which is used to treat major depressive disorder and other mood disorders.
As an intermediate, 1-(4-Fluorophenyl)-1,3-dihydro-3-oxo-5-isobenzofurancarbonitrile contributes to the development of Citalopram by participating in the chemical reactions that lead to the formation of the final compound. This application is significant because it enables the creation of an effective treatment for individuals suffering from depression and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 372941-48-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,9,4 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 372941-48:
(8*3)+(7*7)+(6*2)+(5*9)+(4*4)+(3*1)+(2*4)+(1*8)=165
165 % 10 = 5
So 372941-48-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H8FNO2/c16-11-4-2-10(3-5-11)14-12-6-1-9(8-17)7-13(12)15(18)19-14/h1-7,14H
372941-48-5Relevant articles and documents
Thiyl radical promoted iron-catalyzed-selective oxidation of benzylic sp3 C-H bonds with molecular oxygen
Geng, Shasha,Xiong, Baojian,Zhang, Yun,Zhang, Juan,He, Yun,Feng, Zhang
supporting information, p. 12699 - 12702 (2019/10/28)
A ligand-free iron-catalyzed method for the oxygenation of benzylic sp3 C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.