373-96-6Relevant articles and documents
Α, α-difluoropropionic production of esters
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Paragraph 0098-0100; 0104-0106; 0120-0122, (2016/10/10)
PROBLEM TO BE SOLVED: To provide a practical method of producing α,α-difluoro esters important as pharmaceutical and agricultural chemical intermediates. SOLUTION: The α,α-difluoro esters are produced by reacting α-halogeno-α-fluoro esters with salts or complexes comprising an organic base and hydrogen fluoride. Dehydrohalogenation of side reaction is controlled in the production method. Only α-fluoro-α,β-unsaturated esters of by-products are treated to be brought specifically into a high boiling-point, a boiling point difference gets remarkably large thereby between the α,α-difluoro ester of an objective product and the unsaturated ester of by-product, and a high purity product of the objective product is efficiently obtained by fractional distillation of a simple operation. The method is the practical method of producing the α,α-difluoro esters capable of solving a problem point in a prior technique. COPYRIGHT: (C)2012,JPOandINPIT
Substituted 1,3-thiazole compounds, their production and use
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, (2008/06/13)
(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.
THERMAL DECOMPOSITION OF 2,2-DIFLUOROPROPIONYL PEROXIDE IN HYDROCARBON SOLVENTS
Zhuravlev, M. V.,Burmakov, A. I.,Bloshchitsa, F. A.,Sass, V. P.,Sokolov, S. V.
, p. 1597 - 1601 (2007/10/02)
The thermal decomposition of 2,2-difluoropropionyl peroxide in heptane is a monomolecular process with a rate constant of 1.1E13 expsec-1.The main gaseous products from the decomposition of the peroxide in heptane and isooctane are 1,1-difluoroethane, 1,1-difluoroethylene, and 2,2,3,3-tetrafluorobutane.The CH3CF2. radicals generated in this process take part in the abstraction of hydrogen atoms from the solvent, disproportionation, and recombination.The decomposition of the peroxide at low initial concentrations in heptane can be used as a method for the generation of CH3CF2. radicals for kinetic investigations.