373368-68-4

Basic information

• Product Name: (R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID
• Synonyms: (R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID
• CAS NO: 373368-68-4
• Molecular Weight: 272.301
• Mol File: 373368-68-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID(373368-68-4)
• EPA Substance Registry System: (R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID(373368-68-4)

Safety Data

• Hazardous Substances Data: 373368-68-4(Hazardous Substances Data)

Usage

Description

(R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID is an organic compound characterized by a 2-hydroxypropanoic acid molecule with a benzyloxy substituent attached to the phenyl ring. As a chiral compound, it possesses an (R) configuration at the stereocenter, which is crucial for its potential applications and interactions.

Uses

Used in Pharmaceutical Industry:
(R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID is used as a building block for the synthesis of various drugs and pharmaceutical products. Its unique structure and chirality make it a valuable component in the development of new medications.
Used in Cardiovascular Treatment:
(R)-3-(4-(BENZYLOXY)PHENYL)-2-HYDROXYPROPANOIC ACID is being studied for its potential therapeutic applications, particularly in the treatment of cardiovascular diseases and related conditions. Its biological activities are of interest to researchers and pharmaceutical companies seeking to develop novel treatments for heart-related ailments.

Upstream product

• 100-39-0 benzyl bromide 
• 89919-57-3 (R)-3-(4-hydroxyphenyl)lactic acid 
• 65733-15-5 (R)-2-amino-3-(4-(benzyloxy)phenyl)propanoic acid 
• 1431505-99-5 (Z)-methyl 3-(4-benzyloxyphenyl)-2-pivaloyloxyacrylate 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1431505-92-8 methyl 3-(4-benzyloxyphenyl)-2-hydroxyacrylate 
• 1431505-87-1 (E/Z)-methyl 3-(4-benzyloxyphenyl)-2-dimethylaminoacrylate 

Downstream Products

• 847268-21-7 ethyl (2R)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate 
• 313952-13-5 (R)-2-acetyloxy-3-(4-benzyloxyphenyl)propionic acid 
• 89919-57-3 (R)-3-(4-hydroxyphenyl)lactic acid 
• 1416820-94-4 (R)-2-ethoxy-3-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)phenyl)propanoic acid 
• 1416820-93-3 (R)-ethyl 2-ethoxy-3-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)phenyl)propanoate 
• 1416820-83-1 ethyl (2R)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoate 
• 1416820-84-2 (2R)-2-ethoxy-3-{4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl}propanoic acid 
• 222555-05-7 ethyl (2R)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 1034524-65-6 C₂₄H₃₁NO₅ 
• 482656-47-3 ethyl (2R)-3-[4-(benzyloxy)phenyl]-2-hydroxypropanoate 

Relevant articles and documents

Enantioselective reduction of 3-aryl-2-oxo-propanoic acids: A comparison of enzymatic and transition-metal-catalyzed methods

Phenyllactic acids are important constituents of depsipeptides, which are a large class of natural products expressing a wide range of biological activities. Despite there being several methods for the enantioselective synthesis of α-hydroxy acids, almost no studies are available addressing the substrate selectivity of transition-metal and enzyme-catalyzed methods for the preparation of substituted phenyllactic or more general aryllactic acids. We report herein comparative results for Rh-DiPAMP (DiPAMP = 1,2-ethandiylbis[(o- methoxyphenyl)phenylphosphane]) and lactate dehydrogenase catalyzed enantioselective reductions of several 3-aryl-2-oxopropanoic acids. Phenyllactic acids are important constituents of depsipeptides, which are a large class of natural products expressing a wide range of biological activities. A comparative study of transition-metal and lactate dehydrogenase catalyzed enantioselective reductions of several 3-aryl-2-oxopropanoic acids as valuable sources for enantiomerically pure phenyllactic acids is described. Copyright

NOVEL ANTIDIABETIC COMPOUNDS

The present invention provides novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, their tautomeric forms, their stereoisomers, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of diabetes and related diseases.

PROCESS FOR PREPARING 3-ARYL-2-HYDROXY PROPANOIC ACID DERIVATIVES WITHOUT RESOLUTION

The present invention discloses an improve process for the preparation of S (-) and R (+) 3-aryl-2-hydroxy propanoic acid derivatives without any resolution involved.