373604-97-8

Basic information

• Product Name: (S)-2-[(S)-3-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-2-hydroxy-butyrylamino]-4-methyl-pentanoic acid methyl ester
• Synonyms: (S)-2-[(S)-3-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-2-hydroxy-butyrylamino]-4-methyl-pentanoic acid methyl ester
• CAS NO: 373604-97-8
• Molecular Weight: 594.706
• Mol File: 373604-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[(S)-3-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-2-hydroxy-butyrylamino]-4-methyl-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(S)-3-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-2-hydroxy-butyrylamino]-4-methyl-pentanoic acid methyl ester(373604-97-8)
• EPA Substance Registry System: (S)-2-[(S)-3-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoylamino)-2-hydroxy-butyrylamino]-4-methyl-pentanoic acid methyl ester(373604-97-8)

Safety Data

• Hazardous Substances Data: 373604-97-8(Hazardous Substances Data)

Upstream product

• 158340-98-8 methyl 2-isobutyl-α-isocyanoacetate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 54259-27-7 (S)-methyl 2-formamido-4-methylpentanoate 
• 276888-31-4 2-[2-(5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoyloxy)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-4-methyl-pentanoic acid methyl ester 

Downstream Products

• 137563-63-4 Eurystatin A 

Relevant articles and documents

Concise total synthesis of the prolyl endopeptidase inhibitor eurystatin A via a novel Passerini reaction-deprotection-acyl migration strategy

The Passerini reaction between suitably protected alaninal, leucine isonitrile, and ornithine components delivered adducts 10a,b in high yield. Orthogonal N-deprotection of 10a led, via a smooth O- to N-acyl migration, to 11, which constitutes the entire skeleton of the eurystatins. Subsequent deprotection, macrocyclization, elaboration, and final oxidation steps efficiently afforded eurystatin A 1a in high overall yield.