37394-93-7Relevant articles and documents
Synthesis and Anti-Arrhythmic Activity of the Chloride and Salicylate Salts of Morpholinoacetic Acid Ortho-Toluidide
Gashkova,Rudakova,Syropyatov, B. Ya.
, p. 641 - 643 (2017)
Acylation of ortho-toluidine hydrochloride by chloroacetylchloride followed by amination by morpholine in the presence of an excess of Et3N produced morpholinoacetic acid ortho-toluidide and its salicylate salt. The acute toxicity and anti-arrh
Synthesis of novel 1,2,3-triazoles bearing 2,4 thiazolidinediones conjugates and their biological evaluation
Kulkarni, Pravin S.,Karale, Sanjay N.,Khandebharad, Amol U.,Agrawal, Brijmohan R.,Sarda, Swapnil R.
, p. 2035 - 2046 (2021/02/05)
Searching for new active molecules against M. Bovis BCG and Mycobacterium tuberculosis (MTB) H37Ra, a focused of 1,2,3-triazoles-incorporated 2,4 thiazolidinedione conjugates have been efficiently prepared via a click chemistry approach cyclocondensation of 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (4), aryl aldehyde (5a–l), and mercapto acetic acid (6) with good to promising yields. The newly synthesized compounds were tested against drug-sensitive MTB and BCG. In particular, compounds 8g, 8h, 8j and 8l are highly potent against both the strains with IC90 values in the range of 1.20–2.70 and 1.24–2.65?μg/mL, respectively. Based on the results from the antitubercular activity, SAR for the synthesized series has been developed. Most of the active compounds were non-cytotoxic against MCF-7, HCT 116 and A549 cell lines. Most active compounds were having a higher selectively index, which suggested that these compounds were highly potent.
Synthesis, Characterization and Thermal Study of some new Organochalcogenide compounds containing arylamide group
Hassan,Abdulwahid,Al-Luaibi,Al-Jadaan
, p. 5009 - 5015 (2021/08/31)
Two Series of organochalcogen compounds were prepared. The first series was prepared by the reaction of 2-chloro-N-arylacetamide (where aryl is benzyl, phenyl, o-toluene, or p-toluene) with sodium hydrogen selenide (prepared in situ) to give diorganyl selenide compounds (R2Se). The second series was prepared by reaction of N-benzyl-2-chloro-N-(2-chloroacetyl) acetamide with sodium chalcogenate, Na2E (where E= S, Se, and Te) to give the corresponding cyclic chalcogenide compounds. Diiodo derivatives of cyclic selenide and telluride were also prepared. The thermal stability of the new selenium compounds (R2Se) were decomposed at 300°C. Thermogram showed a phase transfer point between 120-150°C indicating that these compounds may act as liquid crystal compounds. All new compounds were characterized by CHN elemental analysis, UV-Visible, FT-IR and 1H NMR spectroscopic data.