374067-96-6

Basic information

• Product Name: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide
• Synonyms: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide
• CAS NO: 374067-96-6
• Molecular Formula: C₁₀H₁₅NO₃S
• Molecular Weight: 229.3
• Product Categories: Chemical Amines;Amines;Aromatics;Sulfur & Selenium Compounds;Amines, Aromatics, Sulfur & Selenium Compounds
• Mol File: 374067-96-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100-102°C
• Boiling Point: 398.906°C at 760 mmHg
• Flash Point: 195.052°C
• Appearance: /
• Density: 1.256g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Refrigerator
• Solubility: DMSO, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(374067-96-6)
• EPA Substance Registry System: 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide(374067-96-6)

Safety Data

• Hazardous Substances Data: 374067-96-6(Hazardous Substances Data)

Usage

Description

4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide, with the CAS number 374067-96-6, is an organic compound characterized by its off-white powder form. It is primarily utilized in the field of organic synthesis, contributing to the creation of various chemical products and materials.

Uses

Used in Organic Synthesis:
4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide is used as a synthetic intermediate for the production of various organic compounds. Its unique chemical structure allows it to participate in a range of reactions, facilitating the synthesis of complex molecules and contributing to the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide is used as a building block for the development of novel drug candidates. Its versatile chemical properties enable it to be incorporated into the structures of potential therapeutic agents, potentially leading to the discovery of new medicines with improved efficacy and safety profiles.
Used in Agrochemical Industry:
4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide also finds application in the agrochemical industry, where it is employed in the synthesis of new pesticides and other crop protection agents. Its integration into these products can enhance their performance, leading to more effective solutions for managing pests and diseases in agriculture.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-(2-Hydroxy-1,1-dimethylethyl)benzenesulfonamide is used as a key component in the development of advanced materials with specific properties. These materials can be tailored for various applications, such as in coatings, adhesives, and polymers, where their unique characteristics can provide enhanced performance and functionality.

InChI:InChI=1/C10H15NO3S/c1-10(2,7-12)8-3-5-9(6-4-8)15(11,13)14/h3-6,12H,7H2,1-2H3,(H2,11,13,14)

Upstream product

• 374067-95-5 2-methyl-2-(4-sulfamoylphenyl)propionic acid 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 374067-94-4 ethyl 2-methyl-2-(4-sulfamoylphenyl)propionate 
• 321565-78-0 ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 

Downstream Products

• 245118-94-9 N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)-4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide 
• 245118-89-2 N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)-4-(1,1-dimethyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzenesulfonamide 
• 169679-53-2 N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-(4-methylphenyl)-4-pyrimidinyl]-4-(2-hydroxy-1,1-dimethylethyl)-benzenesulfonamide 
• 245118-90-5 4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide 
• 374067-98-8 2-(4-(N-acetyl-N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate 
• 374067-99-9 2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate 
• 245118-91-6 N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)-4-(1,1-dimethyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzenesulfonamide 
• 374068-00-5 2-(4-(N-(5-acetoxymethyl)phenyl-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N-acetylsulfamoyl)phenyl)-2-methylpropyl acetate 
• 169677-18-3 C₂₃H₂₇N₃O₅S 
• 253688-62-9 Ro 64-1056 

Relevant articles and documents

Chemical synthesis method of bosentan metabolite

The invention discloses a chemical synthesis method of bosentan metabolite. According to the method disclosed by the invention, the bosentan metabolite is obtained from 2, 2-dimethyl methyl phenylacetate through six-step reaction. The whole preparation method is high in operability, high in preparation efficiency and low in production cost, and industrial mass production can be achieved. The bosentan metabolite prepared by the invention is higher in bioavailability, can directly play a role in resisting hypertension, and is lower in adverse reaction.