374072-15-8

Basic information

• Product Name: 6,8-dibenzyloxy-7-methoxy-2-trifluoroacetyl-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-diene-4'-one
• Synonyms: 6,8-dibenzyloxy-7-methoxy-2-trifluoroacetyl-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-diene-4'-one
• CAS NO: 374072-15-8
• Molecular Weight: 563.573
• Mol File: 374072-15-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6,8-dibenzyloxy-7-methoxy-2-trifluoroacetyl-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-diene-4'-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-dibenzyloxy-7-methoxy-2-trifluoroacetyl-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-diene-4'-one(374072-15-8)
• EPA Substance Registry System: 6,8-dibenzyloxy-7-methoxy-2-trifluoroacetyl-2,3,4,5-tetrahydro-1H-[2]benzazepine-5-spiro-1'-cyclohexa-2',5'-diene-4'-one(374072-15-8)

Safety Data

• Hazardous Substances Data: 374072-15-8(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 13326-69-7 methyl 3,5-bis(benzyloxy)-4-methoxybenzoate 
• 24093-81-0 methyl 3,5-dihydroxy-4-methoxybenzoate 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 99-24-1 methyl galloate 
• 27229-56-7 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 
• 412009-82-6 N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethylamine 
• 374072-07-8 N-(3,5-dibenzyloxy-4-methoxy)benzyl-N-(4-hydroxyphenyl)ethyltrifluoroacetamide 

Relevant articles and documents

A new H2O2/acid anhydride system for the iodoarene-catalyzed C-C bond-forming reactions of phenols

(Chemical Equation Presented) We have succeeded in the first versatile iodoarene-catalyzed C-C bond-forming reactions by development of a new reoxidation system at low temperatures using stoichiometric bis(trifluoroacetyl) peroxide A in 2,2,2-trifluoroethanol (TFE). The catalytic system supplies a wide range of substrates and functional availabilities sufficient to be used in the key synthetic process of producing biologically important Amaryllidaceae alkaloids.

An efficient synthesis of (±)-narwedine and (±)-galanthamine by an improved phenolic oxidative coupling

Old problems, new ideas! The biometic phenol coupling of norbelladine derivatives such as 1 (Bn = benzyl) to form galanthamine (2), a drug used in the treatment of Alzheimer's disease, has been greatly improved by the use of the hypervalent-iodine oxidation regeant phenyliodine(III) bis(triflouroacetate) (PIFA).