37418-60-3 Usage
Description
1-(prop-2-ynyl)cyclobutanol is an organic compound that features a cyclobutanol ring with a prop-2-ynyl group attached to the first carbon. This unique structure endows it with specific reactivity and properties that make it suitable for use in various chemical reactions and applications.
Uses
Used in Pharmaceutical Industry:
1-(prop-2-ynyl)cyclobutanol is used as a reactant for the preparation of condensed pyrimidine compounds, which serve as RET inhibitors. These inhibitors are important in the development of treatments for various diseases, including cancer and other disorders related to the abnormal activity of the RET receptor tyrosine kinase.
The specific use of 1-(prop-2-ynyl)cyclobutanol in the synthesis of RET inhibitors highlights its potential as a key intermediate in medicinal chemistry, contributing to the advancement of targeted therapies and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 37418-60-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,4,1 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37418-60:
(7*3)+(6*7)+(5*4)+(4*1)+(3*8)+(2*6)+(1*0)=123
123 % 10 = 3
So 37418-60-3 is a valid CAS Registry Number.
37418-60-3Relevant articles and documents
The preparation and structures of several cross-conjugated allenes ("allenic dendralenes")
Lehrich, Friedhelm,Hopf, Henning,Grunenberg, Joerg
experimental part, p. 2705 - 2718 (2011/06/25)
The cross-conjugated allenes ("allenic dendralenes") 2-allenylbuta-1,3-diene (2), 1,1-divinylallene (3, prepared here as the methyl derivative 49), and 1,1-diallenylethene (4) are prepared either by S N2′-substitution processes from appropriate allenic or acetylenic precursors or by base-catalyzed isomerizations of propargylic substrates. Thermal elimination/isomerization routes to these highly unsaturated hydrocarbons require reaction conditions under which these allenes undergo secondary transformations. The new oligoolefins, the structures of which have been calculated by MP2 methods, are interesting substrates for addition and isomerization reactions. The phenomenon of cross-conjugation is extended to allenes; the resulting oligoolefins are predicted to become useful dienes for multiple-Diels-Alder additions allowing the rapid construction of complex carbon frameworks.