37436-25-2

Basic information

• Product Name: 6-ETHYL-2-TETRALONE
• Synonyms: 6-ETHYL-2-TETRALONE;6-ethyl-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 37436-25-2
• Molecular Formula: C12H14O
• Molecular Weight: 174.24
• Mol File: 37436-25-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 159 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.052±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-ETHYL-2-TETRALONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ETHYL-2-TETRALONE(37436-25-2)
• EPA Substance Registry System: 6-ETHYL-2-TETRALONE(37436-25-2)

Safety Data

• Hazardous Substances Data: 37436-25-2(Hazardous Substances Data)

Usage

General Description

6-Ethyl-2-tetralone is a chemical compound with the molecular formula C14H16O. It is a bicyclic ketone that is commonly used in organic synthesis and as a precursor in the production of pharmaceuticals and fragrances. It is a pale yellow liquid with a sweet, floral odor and is a key intermediate in the synthesis of various biologically active compounds. 6-Ethyl-2-tetralone is also used as a starting material in the preparation of other organic compounds such as alkaloids and steroids. Its versatile reactivity and functional groups make it a valuable building block in the field of organic chemistry.

Upstream product

• 4133-35-1 6-bromo-2-tetralone 
• 74-96-4 ethyl bromide 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 21388-17-0 2-methoxy-6-ethylnaphthalene 

Relevant articles and documents

Synthesis method of Alectinib

The invention discloses a synthesis method of Alectinib. The method comprises the following steps: carrying out a borating reaction between 6-bromo-3,4-dihydro-2-naphthalenone and n-butyl lithium and then an organic boron reagent; carrying out a catalytic coupling reaction between the obtained 3,4,-dihydro-2-naphthalenone-6-boric acid and bromoethane; carrying out a dimethylation reaction between the obtained 6-ethyl-3,4-dihydro-2-naphthalenone and iodomethane; carrying out a bromination reaction between the obtained 1,1-dimethyl-6-ethyl-3,4-dihydro-2-naphthalenone and a bromination reagent; carrying out a substitution reaction between the obtained 1,1-dimethyl-6-ethyl-7-bromo-3,4-dihydro-2-naphthalenone and 4-(4-piperidyl)morpholine; carrying out a cyclization reaction between the obtained 1,1-dimethyl-6-ethyl-7-[4-(morpholine-4-yl)piperidine-1-yl]-3,4-dihydro-2-naphthalenone and 3-cyanophenylhydrazine; and carrying out an oxidation reaction between the obtained 9-ethyl-6,6-dimethyl-8-[4-(morpholine-4-yl)piperidine-1-yl]-6,11-dihydro-5H-benzo[b]carbazole-3-formonitrile and dichlorodicyanobenzoquinone to obtain a finished product of Alectinib. The synthesis method has the advantages of relatively short route, simplified operation and relatively low cost and is a green and environment-friendly method suitable for industrial production.