37442-45-8

Basic information

• Product Name: Benzenepropanoic acid, b-hydroxy-a-methylene-, ethyl ester
• CAS NO: 37442-45-8
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Mol File: 37442-45-8.mol
• Article Data: 63

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-hydroxy-a-methylene-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-hydroxy-a-methylene-, ethyl ester(37442-45-8)
• EPA Substance Registry System: Benzenepropanoic acid, b-hydroxy-a-methylene-, ethyl ester(37442-45-8)

Safety Data

• Hazardous Substances Data: 37442-45-8(Hazardous Substances Data)

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 140-88-5 ethyl acrylate 
• 100-52-7 benzaldehyde 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 737817-75-3 ethyl 2-benzyloxyphenylmethyl propenoate 
• 451492-21-0 ethyl 3-(2,2-dimethylpropanoylamino)-2-methylene-3-phenylpropanoate 
• 451492-17-4 ethyl 3-benzoylamino-2-methylene-3-phenylpropanoate 
• 1174757-01-7 ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate 
• 1174757-02-8 ethyl (Z)-2-[(diphenoxyphosphoryl)methyl]-3-phenyl-2-propenoate 

Relevant articles and documents

Reevaluation of the mechanism of the Baylis-Hillman reaction: Implications for asymmetric catalysis

(Chemical Equation Presented) One step beyond: Proton transfer (step 3, see scheme), not C-C bond formation (step 2) as previously thought, is the rate-limiting step (RLS) in the initial stage of the Baylis-Hillman reaction, which involves the amine-catal

Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1–100 molpercent) with H2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 molpercent Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept?).

Enantioselective Lewis base catalyzed phosphonyldifluoromethylation of allylic fluorides using a: C -silyl latent pronucleophile

The first enantioselective phosphonyldifluoromethylation is enabled by the use of diethyl (difluoro(trimethylsilyl)-methyl)phosphonate reagent as a latent pronucleophile in the Lewis base catalyzed substitution of allylic fluorides. The reaction proceeds

Azidophosphonium salt-directed chemoselective synthesis of (E)/(Z)-cinnamyl-1H-Triazoles and regiospecific access to bromomethylcoumarins from Morita-Baylis-Hillman adducts

The direct transformation of Morita-Baylis-Hillman (MBH) adducts into molecules of interest is a crucial process wherein allylic hydroxy-protected or halogenated MBH adducts are commonly preferred. Herein, we report an azidophosphonium salt (AzPS)-catalys