37447-35-1 Usage
Description
(Benzyloxycarbonylamino)malonic acid dimethyl ester, also known as BOC-AA-Mal-OMe, is a chemical compound that serves as a protective group for amino acids in organic synthesis. It is an ester derivative of malonic acid with two methyl groups and a carbonyl group, featuring a benzyloxycarbonyl (BOC) protecting group attached to the amino group. (Benzyloxycarbonylamino)malonic acid dimethyl ester is instrumental in peptide synthesis, allowing for selective reactions at other functional groups within the molecule while protecting the amino group.
Uses
Used in Pharmaceutical Synthesis:
(Benzyloxycarbonylamino)malonic acid dimethyl ester is used as a protective group for amino acids in the pharmaceutical industry. It is crucial for controlling reactions and safeguarding sensitive functional groups during the synthesis process, ensuring the successful creation of desired peptide and pharmaceutical compounds.
Used in Peptide Synthesis:
In the field of peptide synthesis, (Benzyloxycarbonylamino)malonic acid dimethyl ester is employed as a protective agent for the amino group of amino acids. This protection allows chemists to perform selective reactions at other functional groups within the molecule, facilitating the synthesis of complex peptide structures with greater precision and efficiency.
Check Digit Verification of cas no
The CAS Registry Mumber 37447-35-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,4,4 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 37447-35:
(7*3)+(6*7)+(5*4)+(4*4)+(3*7)+(2*3)+(1*5)=131
131 % 10 = 1
So 37447-35-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO6/c1-18-11(15)10(12(16)19-2)14-13(17)20-8-9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,14,17)
37447-35-1Relevant articles and documents
Total synthesis of the duocarmycins
Yamada, Ken,Kurokawa, Toshiki,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 6630 - 6631 (2007/10/03)
The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones. Copyright
Structure taste relationships of L aspartyl aminomalonic acid diesters
Fujino,Wakimasu,Mano,Tanaka,Nakajima
, p. 2112 - 2117 (2007/10/13)
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