374589-65-8

Basic information

• Product Name: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-phenyl-
• CAS NO: 374589-65-8
• Molecular Formula: C15H13ClO2
• Molecular Weight: 260.72
• Mol File: 374589-65-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-phenyl-(374589-65-8)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(4-chlorophenyl)-2-phenyl-(374589-65-8)

Safety Data

• Hazardous Substances Data: 374589-65-8(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 134-85-0 4-chlorobenzophenone 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1003006-88-9 C₁₆H₁₃ClO₄ 
• 1147-42-8 5-chloro-2-(phenylcarbonyl)benzoic acid 
• 812685-36-2 5-chloro-2-(2-phenyl-1,3-dioxolan-2-yl)benzoic acid 
• 134-85-0 4-chlorobenzophenone 

Relevant articles and documents

Intermolecular reactions of chlorohydrine anions: Acetalization of carbonyl compounds under basic conditions

Nonenolizable aldehydes and ketones react with 2-chloroethanol and 3-chloropropanol under basic conditions (t-BuOK, DMF/THF) with formation of 2-substituted 1,3-dioxolanes and 1,3-dioxanes, respectively. Conversion of the two-step addition-alkylation process depends on the electrophilicity of the carbonyl group that governs the equilibrium of addition of chloroalkoxides. This method of protection of carbonyl groups in the form of cyclic acetals under kinetically controlled conditions is complementary to the acid-catalyzed reaction with diols.