37460-22-3

Basic information

• Product Name: H-ALA-GLY-ALA-OH
• Synonyms: L-ALANYL GLYCYL-L-ALANINE;H-ALA-GLY-ALA-OH
• CAS NO: 37460-22-3
• Molecular Formula: C8H15N3O4
• Molecular Weight: 217.22
• Mol File: 37460-22-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: H-ALA-GLY-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALA-GLY-ALA-OH(37460-22-3)
• EPA Substance Registry System: H-ALA-GLY-ALA-OH(37460-22-3)

Safety Data

• Hazardous Substances Data: 37460-22-3(Hazardous Substances Data)

Usage

General Description

H-ALA-GLY-ALA-OH is a peptide consisting of three amino acids - alanine, glycine, and alanine, connected by peptide bonds. Alanine is a non-essential amino acid that plays a crucial role in energy metabolism and protein synthesis, while glycine is a simple amino acid that is essential for the production of heme, nucleic acids, and antioxidants. The presence of these amino acids in H-ALA-GLY-ALA-OH suggests potential benefits for supporting various biological functions, such as muscle building, immune system regulation, and antioxidant defense. Overall, H-ALA-GLY-ALA-OH is a peptide compound with the potential to contribute to overall health and well-being due to its amino acid composition and biological activities.

Upstream product

• 3695-73-6 glycyl-L-alanine 

Relevant articles and documents

Methyl group steric effects on the kinetics of the copper(II)-tripeptide reactions with triethylenetetramine

Rates of reaction of triethylenetetramine (trien) with doubly deprotonated (tripeptido)cuprate(II) complexes are measured as a function of the number and position of methyl groups in the amino acid residues. Twelve tripeptides that consist of glycyl (G), L-alanyl (A), and α-aminoisobutyryl (Aib) residues are compared. The Cu(H-2Aib3)- complex reacts 8 orders of magnitude more slowly with trien than does the Cu(H-2G3)- complex. Methyl groups on the α-carbon of the second and third amino acid residues (from the amino terminus) decrease the rate of the trien substitution reaction to a much greater extent than methyl groups on the first residue. An empirical correlation between the second-order rate constant (Ktrien, M-1 s-1 at 25.0°C, pH ? 11) and the number and position of the methyl groups is found: log ktrien = 6.7 - 0.2C1 - 2.2C2 - 1.6C3, where Ci denotes the number of methyl groups in the ith amino acid residue. The enormous changes in reactivity are attributed primarily to steric effects in these ligand-ligand exchange reactions.