37466-41-4

Basic information

• Product Name: L-Tyrosine, 3-hydroxy-O-Methyl-, Methyl ester
• Synonyms: L-Tyrosine, 3-hydroxy-O-Methyl-, Methyl ester
• CAS NO: 37466-41-4
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.2411
• Mol File: 37466-41-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Tyrosine, 3-hydroxy-O-Methyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, 3-hydroxy-O-Methyl-, Methyl ester(37466-41-4)
• EPA Substance Registry System: L-Tyrosine, 3-hydroxy-O-Methyl-, Methyl ester(37466-41-4)

Safety Data

• Hazardous Substances Data: 37466-41-4(Hazardous Substances Data)

Upstream product

• 132513-32-7 3-hydroxy-O-methyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester 
• 159750-00-2 (S)-2-Azido-3-<3-(benzyloxy)-4-methoxyphenyl>propionic acid methyl ester 
• 621-59-0 isovanillin 
• 36418-96-9 3-<3-(Benzyloxy)-4-methoxyphenyl>propionic acid 
• 537-73-5 isoferulic acid 
• 1135-15-5 dihydroisoferulic acid 
• 1027907-04-5 C₂₂H₂₆O₅ 
• 1027602-57-8 (S)-2-Azido-3-<3-(benzyloxy)-4-methoxyphenyl>propionic acid 
• 159749-96-9 <3-(Benzyloxy)-4-methoxyphenyl>propionic acid benzyl ester 
• 159749-97-0 (4S)-3-(Benzyloxy)-4-methoxy-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene 
• 159749-98-1 (4S,2S)-3-(Benzyloxy)-4-methoxy-<2-azido-3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene 
• 110774-03-3 L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester 
• 79677-60-4 3-acetyl-O-methyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester 
• 152429-80-6 3-acetoxy-O-methyl-N-<(phenylmethoxy)carbonyl>-L-tyrosine methyl ester 

Downstream Products

• 159749-95-8 N--O-methyl-L-tyrosyl>-3-hydroxy-4-methoxy-L-phenylalanine methyl ester 
• 152429-94-2 (S)-2-Benzylamino-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester 
• 1026064-05-0 3-hydroxy-O-methyl-N-<4-iodo-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester 
• 138571-38-7 3-hydroxy-O-methyl-N-<4-iodo-N-methyl-N-<(1,1-dimethylethoxy)carbonyl>-L-phenylalanyl>-L-tyrosine methyl ester 
• 118459-90-8 (S)-3-<4-<2-Carboxy-2-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>phenoxy>-O-methyl-N--L-tyrosinyl>-L-tyrosine α-methyl ester 
• 159750-11-5 (S)-3-<4-<2-<<(1,1-Dimethylethoxy)carbonyl>amino>-3-oxo-3-(2-bromoethoxy)propyl>phenoxy>-O-methyl-N--L-tyrosinyl>-L-tyrosine α-methyl ester 
• 156538-95-3 (S)-3-<4-<2-<<(1,1-Dimethylethoxy)carbonyl>amino>-3-oxo-3-(2-iodoethoxy)propyl>phenoxy>-O-methyl-N--L-tyrosinyl>-L-tyrosine α-methyl ester 
• 152429-84-0 cyclo-(4-iodo-L-phenylalanyl)-3-hydroxy-4-O-methyl-L-tyrosine 
• 138571-40-1 C₄₅H₅₈N₆O₁₂ 
• 138605-23-9 BOC-D-alanyl-L-alanyl-N,O-dimethyl-L-tyrosyl-L-alanyl-N-methyl-L-tyrosyl-O-methyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 138571-36-5 N¹⁵,N²⁹-desmethyl RA-VII 
• 138571-40-1 C₄₄H₅₆N₆O₁₂ 
• 138605-23-9 BOC-D-alanyl-L-alanyl-N,O⁴-dimethyl-L-tyrosyl-L-alanyl-L-tyrosyl-O⁴-methyl-L-tyrosine cyclic 5⁴<*>6³ ether, methyl ester 
• 138571-41-2 (9S,12S)-12-{(S)-2-[(S)-2-{[(S)-2-((R)-2-Amino-propionylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionylamino}-4-methoxy-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid; hydrochloride 

Relevant articles and documents

A Formal Total Synthesis of the ACE Inhibitor K-13. An Application of Arene-Ruthenium Chemistry to Complex Chemical Synthesis

Stoichiometric ruthenium activation of 4-chlorophenylalanine derivatives toward nucleophilic substitution, using phenoxide nucleophiles that are derived from protected dipeptides, allowed the formation of isodityrosine derivatives that are synthetic precursors to the ACE inhibitor K-13.An evaluation of carboxyl blocking groups revealed that a 2-bromoethyl ester is the most useful in terms of its compatibility with ruthenium complexation and subsequent nucleophile addition but that its removal is problematic.Conversion to iodoethyl ester using Finkelstein reaction conditions, in the presence of the peptide and amino acid functionality, provided a solution to this problem, since the iodoethyl group was easily removed on treatment with samarium diiodide.

Synthesis of N29-desmethyl RA-VII. Identification of the pharmacophore of RA-I-VII and deoxybouvardin and reassignment of the subunit functional roles

-