37469-24-2

Basic information

• Product Name: 5,6-diphenyl-1,2,4-triazine-3-thiol
• Synonyms: 5,6-diphenyl-1,2,4-triazine-3(2H)-thione;1,2, 4-Triazine-3(4H)-thione, 5,6-diphenyl-;1,2,4-Triazine-3(2H)-thione, 5,6-diphenyl-;1,2,4-Triazine-3(2H)-thione, 5,6-diphenyl- (9CI);1,2,4-Triazine-3(4H)-thione, 5,6-diphenyl-;5,6-di(phenyl)-2H-1,2,4-triazine-3-thione;5,6-Diphenyl-2H-[1,2,4]triazine-3-thione;5,6-Diphenyl-as-triazine-3(2H)-thione
• CAS NO: 37469-24-2
• Molecular Formula: C₁₅H₁₁N₃S
• Molecular Weight: 265.34
• Mol File: 37469-24-2.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 398.2°Cat760mmHg
• Flash Point: 194.6°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 5,6-diphenyl-1,2,4-triazine-3-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-diphenyl-1,2,4-triazine-3-thiol(37469-24-2)
• EPA Substance Registry System: 5,6-diphenyl-1,2,4-triazine-3-thiol(37469-24-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37469-24-2(Hazardous Substances Data)

Usage

General Description

5,6-diphenyl-1,2,4-triazine-3-thiol, also known as DPTT, is a chemical compound with the molecular formula C15H11N3S. It is a yellow to brown powder with a melting point of 153-156°C. DPTT is primarily used as a rubber accelerator in the production of tires and other rubber products. It assists in the vulcanization process, improving the mechanical and chemical properties of the rubber. Additionally, DPTT has been found to exhibit antioxidant and anti-aging properties, making it a valuable additive in the manufacturing of various rubber goods. Despite its beneficial properties, DPTT should be handled with caution as it can be harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C15H11N3S/c19-15-16-13(11-7-3-1-4-8-11)14(17-18-15)12-9-5-2-6-10-12/h1-10H,(H,16,18,19)

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Downstream Products

• 28735-33-3 5,6-diphenyl-3-methylthio-1,2,4-triazine 
• 4512-00-9 5,6-diphenyl-1,2,4-triazin-3(2H)-one 
• 30131-90-9 5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione 
• 21383-24-4 (5,6-diphenyl-[1,2,4]triazin-3-yl)-hydrazine 
• 106510-63-8 5,5',6,6'-tetraphenyl-bis(1,2,4-triazine)-3,3'-disulfide 
• 30131-95-4 5,6-diphenyl-2,3,4,5-tetrahydro-5-ethoxy-1,2,4-triazine-3-thione 
• 89174-67-4 1-[2-(5,6-Diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-3-(3-methoxy-phenyl)-urea 
• 89174-64-1 1-(4-Bromo-phenyl)-3-[2-(5,6-diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-urea 
• 89174-66-3 1-[2-(5,6-Diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-3-(2-methoxy-phenyl)-urea 
• 89174-65-2 1-[2-(5,6-Diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-3-(4-ethoxy-phenyl)-urea 
• 89174-62-9 1-(3-Chloro-phenyl)-3-[2-(5,6-diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-urea 
• 89174-57-2 1-[2-(5,6-Diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-3-phenyl-urea 
• 89174-60-7 1-[2-(5,6-Diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-3-p-tolyl-urea 
• 89174-63-0 1-(4-Chloro-phenyl)-3-[2-(5,6-diphenyl-[1,2,4]triazin-3-ylsulfanyl)-acetyl]-urea 

Relevant articles and documents

Synthesis, characterization, DFT and TD-DFT study of novel bis(5,6-diphenyl-1,2,4-triazines)

Due to the numerous biological as well as pharmacological activities of 1,2,4-triazine derivatives, we reported a synthesis of novel series of bis(5,6-diphenyl-1,2,4-triazines) via alkylation of 5,6-diphenyl-1,2,4-triazine-3(4H)-thione with the appropriate bis(halo) compounds in ethanolic KOH. The chemical structures of these compounds were confirmed by spectroscopic techniques. The absorption and excited-emission spectra of the studied novel series were monitored experimentally in ethanol solvent. The molecular structures of these triazines were optimized using B3LYP/6–31G(d) level of theory. The electronic absorption and emission spectra of the novel compounds, in gas and ethanol solvent, were calculated using time dependent density functional theory (TDDFT) at mPW1PW91/ 6–31 G (d) level. The obtained theoretical results were compared to experimental ones. The results show that, the computational optical properties of the studied novel series are in agreement with experimental results.

Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies

Aggregation of α-synuclein (α-syn) is one of the central hypotheses for Parkinson's disease (PD), therefore, its inhibition and disaggregation is an optimistic approach for the treatment of PD. Here, we report design, synthesis and in-vitro efficacy studi

Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase

(E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazines analogs 1–27 were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against α-amylase and α-glucosidase enzymes. Out of these twenty-seven synthetic analog

Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation

Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in the pathogenesis of AD and its inhibition is of particular importance in AD treatme