374890-30-9

Basic information

• Product Name: (3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• Synonyms: (3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
• CAS NO: 374890-30-9
• Molecular Weight: 233.267
• Mol File: 374890-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(374890-30-9)
• EPA Substance Registry System: (3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one(374890-30-9)

Safety Data

• Hazardous Substances Data: 374890-30-9(Hazardous Substances Data)

Upstream product

• 344797-51-9 (1'R)-(-)-1-(2'-hydroxy-1'-phenyl-ethyl)-3,4-dihydro-(1H)-pyridin-2-one 

Downstream Products

• 143900-44-1 tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate 

Relevant articles and documents

Unprecedented oxidation of a phenylglycinol-derived 2-pyridone: Enantioselective synthesis of polyhydroxypiperidines

Equation presented The phenylglycinol-derived 2-pyridone 1 undergoes m-CPBA oxidation steroselectively leading to the chiral nonracemic unsaturated bicyclic hydroxylactam 2, from which the enantioselective synthesis of (3R,5R)-3,4,5-trihydroxypiperidine (16) and the formal synthesis of the azasugar epiisofagomine are described. The enantioselective synthesis of (S)-N-Boc-3-hydroxypiperidine and (3R,4S)-3,4-dihydroxypiperidine is also reported.