3749-11-9

Basic information

• Product Name: 1-methyl-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
• CAS NO: 3749-11-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.227
• Mol File: 3749-11-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 304°C at 760 mmHg
• Flash Point: 118.7°C
• Density: 1.084g/cm³
• Vapor Pressure: 0.000898mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 1-methyl-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one(3749-11-9)
• EPA Substance Registry System: 1-methyl-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one(3749-11-9)

Safety Data

• Hazardous Substances Data: 3749-11-9(Hazardous Substances Data)

Usage

Classification

Derivative of benzazepine, cyclic amide

Physical appearance

White solid

Usage

Pharmaceutical research and drug development

Potential applications

Antipsychotic and antidepressant medication

Mechanism of action

Interaction with various neurotransmitter receptors in the brain

Status of research

Ongoing investigation of pharmacological effects

Upstream product

• 74799-85-2 N-(3-methoxycarbonyl-propyl)-N-methyl-anthranilic acid methyl ester 
• 857601-81-1 N-(3-methoxycarbonyl-propyl)-anthranilic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 118670-86-3 N-(but-3-en-1-yl)-2-iodoaniline 
• 615-43-0 2-iodophenylamine 
• 57056-89-0 N-(but-3-en-1-yl)-2-iodo-N-methylaniline 
• 1407968-57-3 4-[N-(2-iodophenyl)-N-methylamino]butanol 
• 1407968-49-3 4-[N-(2-iodophenyl)-N-methylamino]butanal 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1701-57-1 2,3,4,5-tetrahydro-1Hbenzo[b]azepine 
• 4425-15-4 4,5,6,7-tetrahydro-azepino[3,2,1-hi]indole-1,2-dione 

Relevant articles and documents

A Cascade of acid-promoted c-o bond cleavage and redox reactions: From oxa-bridged benzazepines to benzazepinones

A sequence of C-O bond cleavage and redox reactions in oxa-bridged azepines was realized under acid promoted conditions. This protocol provides an atom-economical and straightforward approach to access benzo[b]azepin-5(2H)-ones in high yields. The formal synthesis of tolvaptan was achieved by exploiting this new transformation.