37527-68-7

Basic information

• Product Name: (2-amino-4-methoxyphenyl)(phenyl)methanone
• CAS NO: 37527-68-7
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.2585
• Mol File: 37527-68-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 428.3°C at 760 mmHg
• Flash Point: 219.5°C
• Density: 1.172g/cm³
• Vapor Pressure: 1.53E-07mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: (2-amino-4-methoxyphenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-4-methoxyphenyl)(phenyl)methanone(37527-68-7)
• EPA Substance Registry System: (2-amino-4-methoxyphenyl)(phenyl)methanone(37527-68-7)

Safety Data

• Hazardous Substances Data: 37527-68-7(Hazardous Substances Data)

Usage

Description

(2-amino-4-methoxyphenyl)(phenyl)methanone, also known as 4'-Methoxyacetophenone, is an organic compound with the molecular formula C15H15NO2. It is composed of a phenyl group attached to a methanone group, featuring a methoxy and an amino group substituted on the phenyl ring. This versatile chemical is widely used as an intermediate in the synthesis of pharmaceuticals, fragrances, and other organic compounds. Additionally, it has been studied for its potential biological activities, such as anti-cancer and anti-inflammatory properties, making it a valuable compound in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
(2-amino-4-methoxyphenyl)(phenyl)methanone is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic benefits.
Used in Fragrance Industry:
As an intermediate, (2-amino-4-methoxyphenyl)(phenyl)methanone is used in the creation of fragrances, taking advantage of its reactive functional groups to produce a wide range of scent compounds that can be used in perfumes, cosmetics, and other scented products.
Used in Organic Synthesis:
(2-amino-4-methoxyphenyl)(phenyl)methanone is utilized as a building block in organic synthesis, allowing chemists to construct a variety of organic compounds for research and commercial applications, such as dyes, agrochemicals, and other specialty chemicals.
Used in Biological Research:
(2-amino-4-methoxyphenyl)(phenyl)methanone is employed in biological research as a subject of study for its potential anti-cancer and anti-inflammatory properties, with the aim of discovering new therapeutic agents and understanding their mechanisms of action.
Used in Drug Development:
(2-amino-4-methoxyphenyl)(phenyl)methanone is used in drug development as a lead compound, providing a foundation for the design and optimization of new pharmaceuticals targeting various diseases and conditions.

Upstream product

• 13234-81-6 7-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 108-86-1 bromobenzene 
• 38487-85-3 4-methoxyanthranilonitrile 
• 536-90-3 m-Anisidine 
• 1228191-31-8 C₁₄H₁₁NO₄ 
• 100-58-3 phenylmagnesium bromide 
• 100-47-0 benzonitrile 
• 588-16-9 m-methoxyacetanilide 
• 13740-49-3 N-(2-benzoyl-5-methoxyphenyl)acetamide 
• 4294-95-5 4-methoxyanthranilic acid 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 179104-61-1 (4-methoxy-2-nitrophenyl)-phenyl-methanol 
• 1392300-36-5 4-methoxy-2-(phenylsulfonamido)benzoic acid 

Downstream Products

• 102662-40-8 N-(2-benzoyl-5-methoxy-phenyl)-phthalimide 
• 5358-30-5 8-methoxy-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 132522-16-8 8-methoxy-1-methyl-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one 
• 174635-05-3 1,2-dihydro-7-methoxy-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester 
• 1228190-87-1 C₁₄H₁₁N₃O₂ 
• 1433904-23-4 7-methoxy-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carbonitrile 
• 1440429-84-4 C₁₇H₁₇NO 
• 1440430-15-8 C₂₄H₂₃NO₃S 
• 1440429-60-6 C₂₈H₂₇NO₃S 

Relevant articles and documents

Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines

A novel protocol for asymmetric synthesis of hydroquinazolines bearing C4-tetrasubstituted stereocenters has been achieved through kinetic resolution of 2-amido α-tertiary benzylamines via chiral phosphoric acid catalyzed intramolecular dehydrative cyclizations. This method gave access to both α-tertiary benzylamines and hydroquinazolines with broad scope and high enantioselectivities. An intriguing restricted rotation of the C-N bond was observed for hydroquinazoline products bearing C4-tetrasubstituted stereocenters.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.