37554-40-8

Basic information

• Product Name: Fluquazone
• Synonyms: Fluquazone;6-Chloro-4-phenyl-1-(2,2,2-trifluoroethyl)quinazolin-2(1H)-one;EN-970;6-chloro-4-phenyl-1-(2,2,2-trifluoroethyl)quinazolin-2-one
• CAS NO: 37554-40-8
• Molecular Formula: C₁₆H₁₀ClF₃N₂O
• Molecular Weight: 338.715
• Mol File: 37554-40-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 425.5°Cat760mmHg
• Flash Point: 211.2°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 1.9E-07mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: Fluquazone(CAS DataBase Reference)
• NIST Chemistry Reference: Fluquazone(37554-40-8)
• EPA Substance Registry System: Fluquazone(37554-40-8)

Safety Data

• Hazardous Substances Data: 37554-40-8(Hazardous Substances Data)

Usage

Uses

Anti-inflammatory.

InChI:InChI=1/C16H10ClF3N2O/c17-11-6-7-13-12(8-11)14(10-4-2-1-3-5-10)21-15(23)22(13)9-16(18,19)20/h1-8H,9H2

Upstream product

• 108-20-3 di-isopropyl ether 
• 51-79-6 urethane 
• 22753-80-6 5-chloro-2-[(2,2,2-trifluoroethyl)amino]benzophenone 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 4797-43-7 6-chloro-4-phenyl-2-quinazolinone 
• 75-44-5 phosgene 
• 497-19-8 sodium carbonate 
• 36943-01-8 6-chloro-4-phenyl-1-(2,2,2-trifluoro-ethyl)-3,4-dihydro-1H-quinazolin-2-one 

Relevant articles and documents

Analgesic and myotonolytic preparations

Compositions having enhanced analgesic and myotonolytic activity comprising as active agents (a) an analeptically active quinazolinone and (b) a centrally acting myotonolytic.

1-Polyhaloalkyl-2(1H)-quinazolinone derivatives

1-Polyhaloalkyl-2(1H)-quinazoline derivatives of the formula, STR1 wherein R is polyhaloalkyl having C2 -C4 alkyl; and R1, R2 and R3 are individually hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy, nitro, trifluoromethyl or halogen, have excellent anti-inflammatory and analgesic activities with very low toxicity. These quinazolinone derivatives can be prepared, for example, by reacting a trihalogenoacetamidobenzophenone derivative with ammonia.

Process for preparing quinazolines

Quinazoline derivatives which have anti-inflammatory, antiviral, uricosuric activities are prepared by reacting an indole-2-carbonylazide derivative with an oxidizing agent under mild conditions.