375823-41-9 Usage
Clinical Use
Interleukin inhibitor: Treatment of rheumatoid arthritis in combination with methotrexate
Drug interactions
Potentially hazardous interactions with other drugs
Live vaccines: avoid concomitant administration
Metabolism
Tocilizumab undergoes biphasic elimination from the circulation. The total clearance of tocilizumab is concentration-dependent and is the sum of the linear and non-linear clearance. The concentration-dependent non-linear clearance plays a major role at low tocilizumab concentrations. Once the non-linear clearance pathway is saturated, at higher tocilizumab concentrations, clearance is mainly determined by the linear clearance.
Check Digit Verification of cas no
The CAS Registry Mumber 375823-41-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,5,8,2 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 375823-41:
(8*3)+(7*7)+(6*5)+(5*8)+(4*2)+(3*3)+(2*4)+(1*1)=169
169 % 10 = 9
So 375823-41-9 is a valid CAS Registry Number.