37589-10-9

Basic information

• Product Name: sodium alpha-hydroxy-3,4-methylenedioxytoluene-alpha-sulphonate
• Synonyms: sodium alpha-hydroxy-3,4-methylenedioxytoluene-alpha-sulphonate;(1,3-Benzodioxole-5-yl)hydroxymethanesulfonic acid sodium salt;α-Hydroxy-1,3-benzodioxole-5-methanesulfonic acid sodium salt
• CAS NO: 37589-10-9
• Molecular Formula: C₈H₇O₆S*Na
• Molecular Weight: 254.19235
• EINECS: 253-556-3
• Mol File: 37589-10-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: sodium alpha-hydroxy-3,4-methylenedioxytoluene-alpha-sulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium alpha-hydroxy-3,4-methylenedioxytoluene-alpha-sulphonate(37589-10-9)
• EPA Substance Registry System: sodium alpha-hydroxy-3,4-methylenedioxytoluene-alpha-sulphonate(37589-10-9)

Safety Data

• Hazardous Substances Data: 37589-10-9(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 

Downstream Products

• 80493-81-8 2-Benzo[1,3]dioxol-5-yl-imidazo[1,2-a]pyridin-3-ylamine 
• 86215-81-8 2-(benzo[d][1,3]dioxol-6-yl)-2-hydroxyacetonitrile 
• 120-57-0 piperonal 
• 7464-97-3 1-(3,4-methylenedioxyphenyl)-2-aminoethanol 
• 4421-09-4 piperonylonitrile 
• 3605-01-4 piribedil 

Relevant articles and documents

Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.

Liquid-Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures

The reaction of the bisulfite ion with aldehydes to form charged bisulfite adducts is a well-established method for the purification of aldehydes. This reaction has been modified to create a convenient liquid-liquid extraction method for the removal of aldehydes from mixtures. The use of a water-miscible solvent allows the reaction to occur during a simple 30 s shaking protocol by increasing the contact between the bisulfite ion and the aldehyde. The introduction of an immiscible solvent allows for the extraction of the uncharged organic components away from the bisulfite adduct. The developed protocol is applicable to a wide range of aldehydes, including sterically hindered neopentyl aldehydes. Sterically unhindered cyclic and linear ketones, as well as highly electrophilic ketones, are also removed using this protocol. The mild conditions tolerate a wide range of functional groups, allowing for excellent aldehyde contaminant removal rates with high levels of recovery of the desired component.

Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters

Abstract A total of 51 novel benzimidazoles were synthesized by a 4-step reaction starting from basic compound 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The structure of the novel benzimidazoles was confirmed by mass spectra as well as 1H NMR spectroscopic data. Out of the 51 novel synthesized compounds, 42 of them were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain using BacTiter-Glo Microbial Cell Viability (BTG) method. Results of activity screened using Alamar Blue method was also provided for comparison purposes. Two of the novel benzimidazoles synthesized showed moderately good activity with IC50 of less than 15 μM. Compound 5g, ethyl 2-(4-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-benzo[d]imidazole-5-carboxylate, was found to be the most active with IC50 of 11.52 μM.