37589-80-3 Usage
Description
GTP-GAMMA-S SODIUM SALT, also known as Guanosine 5′-O-(3-thiotriphosphate), tetralithium salt, is a non-hydrolysable analog of GTP. It is characterized by its ability to inhibit phosphodiesterase in photoreceptors, making it a significant compound in various biological and pharmaceutical applications.
Uses
Used in G-Protein Activation Assay:
GTP-GAMMA-S SODIUM SALT is used as a functional assessment tool for the protease-activated receptor 4 (PAR4). It aids in evaluating the receptor's activity and its role in various cellular processes.
Used in Fluorimetric Guanine Nucleotide Exchange Assay:
In the field of G protein alpha subunits (Gα) research, GTP-GAMMA-S SODIUM SALT is utilized as a monitoring agent for the Rac family small guanosine triphosphatase (GTPase) 2 (Rac2)-stimulated activity of phospholipase Cγ2 mutants. This application helps in understanding the intricate mechanisms of G protein signaling and its implications in cellular functions.
Used in Photoreceptor Research:
GTP-GAMMA-S SODIUM SALT is used as an inhibitor of phosphodiesterase in photoreceptors. This application is crucial for studying the role of phosphodiesterase in vision and its potential as a therapeutic target for various retinal diseases.
Used in Pharmaceutical Industry:
GTP-GAMMA-S SODIUM SALT is used as a research compound for the development of new drugs targeting G protein-coupled receptors (GPCRs) and related signaling pathways. Its ability to modulate G protein activity makes it a valuable tool in the discovery and optimization of novel therapeutic agents.
Used in Biomedical Research:
In the field of biomedical research, GTP-GAMMA-S SODIUM SALT is used as an experimental tool to investigate the roles of G proteins and their associated signaling pathways in various physiological and pathological processes. This helps in gaining insights into the molecular mechanisms underlying numerous diseases and the development of targeted therapies.
Biochem/physiol Actions
Guanosine 5′-O-(3-thiotriphosphate) (GTP-γ-S) activates guanine-nucleotide-binding proteins and is slowly hydrolyzed enzymatically. It inhibits guanosine triphosphatase (GTPases) more potently than guanosine triphosphate (GTP),
Check Digit Verification of cas no
The CAS Registry Mumber 37589-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,5,8 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37589-80:
(7*3)+(6*7)+(5*5)+(4*8)+(3*9)+(2*8)+(1*0)=163
163 % 10 = 3
So 37589-80-3 is a valid CAS Registry Number.
