37612-74-1

Basic information

• Product Name: C₁₄H₁₄N₂O
• Synonyms: C₁₄H₁₄N₂O
• CAS NO: 37612-74-1
• Molecular Weight: 226.278
• Mol File: 37612-74-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₄N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₄N₂O(37612-74-1)
• EPA Substance Registry System: C₁₄H₁₄N₂O(37612-74-1)

Safety Data

• Hazardous Substances Data: 37612-74-1(Hazardous Substances Data)

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 104-55-2 3-phenyl-propenal 
• 100-52-7 benzaldehyde 
• 621-82-9 Cinnamic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 29476-22-0 (R)-2-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one 

Relevant articles and documents

Nitroxide-Catalyzed Oxidative Amidation of Aldehydes to Yield N-Acyl Azoles Using Sodium Persulfate

A methodology for the oxidative amidation of aldehydes to yield N-acyl azoles is reported. The approach employs sodium persulfate and a catalytic amount of a nitroxide and is applicable to a range of structurally diverse substrates.

Enantioselective Synthesis of N?H-Free 1,5-Benzothiazepines

An enantioselective sulfa-Michael-cyclization reaction was developed for the synthesis of 1,5-benzothiazepines with versatile pharmacological activities. The reaction between 2-aminothiophenol and α,β-unsaturated pyrazoleamides gave direct access to N?H-free 1,5-benzothiazepines in the presence of a chiral N,N′-dioxide/Yb(OTf)3complex. Excellent enantioselectivities (up to 96 % ee) and high yields (up to 99 %) were obtained for a broad range of substrates under mild reaction conditions. This method provided a facile approach to the antidepressant drug (R)-(?)-Thiazesim.

Asymmetric diels alder reaction using pyrazole derivatives as a chiral catalyst

N-Acylpyrazoles (1) were promising as good dienophiles, which were easily converted into the desired carboxylic derivatives. Bis(pyrazolyl)methanes, which were derived from chiral pyrazoles, showed the activity of chiral catalyst. Particularly 10 mol% of bis(isomenthopyrazol-1,1′-yl)methane (8a) catalyzed enantioselectively the Diels Alder reaction up to 40 % ee by the formation of complex with Mg(ClO4)2.