37622-42-7

Basic information

• Product Name: butyl 2,4-dihydroxybenzoate
• Synonyms: Benzoic acid, 2,4-dihydroxy-, butyl ester; Butyl 2,4-dihydroxybenzoate
• CAS NO: 37622-42-7
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.2265
• Mol File: 37622-42-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.2°C at 760 mmHg
• Flash Point: 147.2°C
• Density: 1.21g/cm³
• Vapor Pressure: 3.17E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: butyl 2,4-dihydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl 2,4-dihydroxybenzoate(37622-42-7)
• EPA Substance Registry System: butyl 2,4-dihydroxybenzoate(37622-42-7)

Safety Data

• Hazardous Substances Data: 37622-42-7(Hazardous Substances Data)

Upstream product

• 89-86-1 4-hydroxysalicylic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 118683-30-0 4-(4-Carboxy-2-methoxy-benzyloxy)-2-hydroxy-3-propyl-benzoic acid butyl ester 

Relevant articles and documents

Design of antibacterial agents: Alkyl dihydroxybenzoates against xanthomonas citri subsp. citri

Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.

Nematocidal principles in 'oakmoss absolute' and nematocidal activity of 2,4-dihydroxybenzoates

Nematocidal principles obtained from oakmoss absolute were identified as methyl 2,4-dihydroxy-3,6-dimethylbenzoate (2), ethyl 3-formyl-2,4-dihydroxy-6-methylbenzoate (4), and ethyl 5-chloro-3-formyl-2,4-dihydroxy-6-methylbenzoate (7). In relation to their structures, the nematocidal activity of 2,4-dihydroxybenzoates of methyl to tetradecyl was tested and the strongest activity was found in the octyl ester (minimal lethal concentration=13 μM).