37622-54-1Relevant articles and documents
Metabolite profile of Nectandra oppositifolia Nees & Mart. And assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses
Conserva, Geanne A. Alves,Quiros-Guerrero, Luis M.,Costa-Silva, Thais A.,Marcourt, Laurence,Pinto, Erika G.,Tempone, Andre G.,Fernandes, Jo?o Paulo S.,Wolfender, Jean-Luc,Queiroz, Emerson F.,Lago, Jo?o Henrique G.
, (2021/03/15)
EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts were subjected to successive liquid-liquid partitioning to afford bioactive CH2Cl2 fractions. UHPL
Molecular design of multifunctional food additives: Antioxidative antifungal agents
Nihei, Ken-Ichi,Nihei, Atsuko,Kubo, Isao
, p. 5011 - 5020 (2007/10/03)
A series of alkyl 3,4-dihydroxybenzoates (protocatechuates) was synthesized, and their fungicidal activity against Saccharomyces cerevisiae was assayed using a 2-fold serial broth dilution method. Nonyl and octyl 3,4-dihydroxybenzoate were noted to be the most effective against this yeast with the minimum fungicidal concentration of 12.5 μg/mL each. The activity was found to correlate with the hydrophobic alkyl chain length. The time-kill curve study showed that nonyl 3,4-dihydroxybenzoate was fungicidal against S. cerevisiae at any growth stage and this activity was not influenced by pH values. The fungicidal activity of alkyl 3,4-dihydroxybenzoates was noted in combination with their ability to disrupt the native membrane-associated function nonspecifically as surface-active agents (surfactants) and to inhibit the respiratory electron transport. However, the primary fungicidal activity of nonyl 3,4-dihydroxybenzoate likely comes from its ability to act as a surfactant.
