376382-11-5

Basic information

• Product Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
• Synonyms: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione;BRD 7389;3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]-;1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione;1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione;Insulin Expression Inducer, BRD7389
• CAS NO: 376382-11-5
• Molecular Formula: C24H18N2O2
• Molecular Weight: 366
• Mol File: 376382-11-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 655.0±55.0 °C(Predicted)
• Appearance: orange/
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Store at +4°C
• Solubility: DMSO: >20mg/mL
• PKA: 11.31±0.40(Predicted)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• CAS DataBase Reference: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(376382-11-5)
• EPA Substance Registry System: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione(376382-11-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 376382-11-5(Hazardous Substances Data)

Usage

Description

1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione is a complex organic compound with a unique molecular structure. It is characterized by its naphthoquinoline core, which is fused with a phenylethylamino group. 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione exhibits a range of biological activities and has potential applications in various fields due to its structural properties and interactions with biological targets.

Uses

Used in Pharmaceutical Industry:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione is used as a potential therapeutic agent for targeting specific biological pathways. Its unique structure allows it to interact with various cellular targets, making it a promising candidate for the development of new drugs to treat a range of diseases.
Used in Chemical Research:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione is also used as a research tool in the field of chemistry, particularly in the study of molecular interactions, structure-activity relationships, and the development of novel synthetic methods. Its complex structure provides a platform for exploring new chemical reactions and understanding the underlying mechanisms.
Used in Drug Design and Development:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione serves as a starting point for the design and development of new drugs. Its structural features can be modified to optimize its pharmacological properties, such as potency, selectivity, and bioavailability, leading to the creation of more effective and safer therapeutic agents.

References

1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099 2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194 3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon cancer cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191