376591-95-6

Basic information

• Product Name: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID
• Synonyms: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID;2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid;2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid;3-(2-hydroxy-3-nitrophenyl)benzoic acid;Eltrombopag olamine Intermediate 2;Eltrombopag o
• CAS NO: 376591-95-6
• Molecular Formula: C₁₃H₉NO₅
• Molecular Weight: 259.216
• Mol File: 376591-95-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 452.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.460±0.06 g/cm3(Predicted)
• Storage Temp.: Room Temperature
• Solubility: Tetrahydrofuran; Methanol
• PKA: 3.96±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(376591-95-6)
• EPA Substance Registry System: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(376591-95-6)

Safety Data

• Hazardous Substances Data: 376591-95-6(Hazardous Substances Data)

Usage

Uses

3’-Nitro-2’-hydroxy[1,1’]-biphenyl-3-carboxylic Acid is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Upstream product

• 376591-94-5 2'-methoxy-3'-nitrobiphenyl-3-carboxylic acid 
• 893736-72-6 2′-hydroxy[1,1-biphenyl]-3-carboxylic acid 
• 88-75-5 2-hydroxynitrobenzene 
• 618-51-9 3-Iodobenzoic acid 
• 95-56-7 2-hydroxybromobenzene 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 25487-66-5 3-Carboxyphenylboronic acid 

Downstream Products

• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 
• 376591-97-8 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride 

Relevant articles and documents

Preparation method of Eltrombopag key intermediate 3'-amino-2'-hydroxybiphenyl-3-carboxylic acid

The invention discloses a preparation method of an Eltrombopag key intermediate 3'-amino-2'-hydroxybiphenyl-3-carboxylic acid. The preparation method comprises the following steps: (1) nitrating o-bromophenol with a nitrating reagent by using water as a s

Synthetic method of eltrombopag intermediate

The application discloses a synthetic method of an eltrombopag intermediate, comprising: subjecting 2-aminophenol derivative shown as formula (II) as a raw material to react with an aromatic reagent shown as formula (III) to obtain an intermediate product shown as formula (IV); using the intermediate product shown as formula (IV) as a raw material to prepare the eltrombopag intermediate shown as formula (I), wherein R1 is selected from amino derivatives, and R2 is selected from halogen and sulfonyloxy group. The synthetic method has few reaction steps; the starting material is simple; the synthetic method is simpler, more economical and greener.

THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS

Disclosed herein are substituted arylhydrazino compounds, pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.