3766-68-5

Basic information

• Product Name: 1-(2,4,6-triethylphenyl)ethanone)
• Synonyms: 1-(2,4,6-triethylphenyl)ethanone);Ethanone,1-(2,4,6-triethylphenyl)-;2',4',6'-Triethylacetophenone;NSC 28479
• CAS NO: 3766-68-5
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.308
• Mol File: 3766-68-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 317.5 °C at 760 mmHg
• Flash Point: 133 °C
• Appearance: /
• Density: 0.931 g/cm³
• Vapor Pressure: 0.000384mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 1-(2,4,6-triethylphenyl)ethanone)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,6-triethylphenyl)ethanone)(3766-68-5)
• EPA Substance Registry System: 1-(2,4,6-triethylphenyl)ethanone)(3766-68-5)

Safety Data

• Hazardous Substances Data: 3766-68-5(Hazardous Substances Data)

Usage

General Description

1-(2,4,6-triethylphenyl)ethanone, also known as triethylphenylketone, is an aromatic ketone with the chemical formula C16H22O. It is a clear, colorless to pale yellow liquid with a sweet, floral, and woody odor. 1-(2,4,6-triethylphenyl)ethanone) is primarily used as a fragrance ingredient in perfumes and personal care products due to its pleasant odor. It is also used as a flavoring agent in the food industry, particularly in baked goods and confectionery products. Additionally, 1-(2,4,6-triethylphenyl)ethanone is used as an intermediate in the production of other chemicals and pharmaceuticals. However, it should be handled with care as it can cause skin and eye irritation and is harmful if swallowed or inhaled.

InChI:InChI=1/C14H20O/c1-5-11-8-12(6-2)14(10(4)15)13(7-3)9-11/h8-9H,5-7H2,1-4H3

Upstream product

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Relevant articles and documents

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5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII

Inhibitory activity of a congeneric set of 23 phenyl-substituted 5-phenyl-pyrazole-3-carboxylic acids toward human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms I, II, IX and XII was evaluated by a stopped-flow CO2 hydrase assay. These compounds exerted a clear, selective inhibition of hCA IX and XII over hCAI and II, with Ki in two to one digit micromolar concentrations (4-50 μM). Derivatives bearing bulkier substituents in para-position of the phenyl ring inhibited hCA XII at one-digit micromolar concentrations, while derivatives having alkyl substituents in both ortho- and meta-positions inhibited hCA IX with Kis ranging between 5 and 25 μM. Results of docking experiments offered a rational explanation on the selectivity of these compounds toward CA IX and XII, as well as on the substitution patterns leading to best CA IX or CA XII inhibitors. By examining the active sites of these four isoforms with GRID generated molecular-interaction fields, striking differences between hCA XII and the other three isoforms were observed. The field of hydrophobic probe (DRY) appeared significantly different in CA XII active site, comparing to other three isoforms studied. To the best of our knowledge such an observation was not reported in literature so far. Considering the selectivity of these carboxylates towards membrane-associated over cytosolic CA isoforms, the title compounds could be useful for the development of isoform-specific non-sulfonamide CA inhibitors.