376644-41-6

Basic information

• Product Name: (2R,3R,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid ethyl ester
• CAS NO: 376644-41-6
• Molecular Weight: 532.634
• Mol File: 376644-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid ethyl ester(376644-41-6)
• EPA Substance Registry System: (2R,3R,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid ethyl ester(376644-41-6)

Safety Data

• Hazardous Substances Data: 376644-41-6(Hazardous Substances Data)

Upstream product

• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 124818-94-6 ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 
• 41219-16-3 2,3,4-trimethoxybenzylamine 
• 72155-45-4 Boc-L-phenylalaninal 

Downstream Products

• 376644-59-6 {(S)-1-[(1S,2R,3R)-1-Benzyl-2-hydroxy-3-[(S)-1-(2-hydroxy-4-methoxy-benzylcarbamoyl)-2-methyl-propylcarbamoyl]-3-(2,3,4-trimethoxy-benzylamino)-propylcarbamoyl]-2,2-dimethyl-propyl}-carbamic acid tert-butyl ester 
• 376644-58-5 (2R,3R,4S)-4-((S)-2-Amino-3,3-dimethyl-butyrylamino)-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid [(S)-1-(2-hydroxy-4-methoxy-benzylcarbamoyl)-2-methyl-propyl]-amide 
• 376644-43-8 [(1S,2R,3R)-1-Benzyl-2-hydroxy-3-[(S)-1-(2-hydroxy-4-methoxy-benzylcarbamoyl)-2-methyl-propylcarbamoyl]-3-(2,3,4-trimethoxy-benzylamino)-propyl]-carbamic acid tert-butyl ester 
• 376644-40-5 (2R,3R,4S)-4-Amino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid [(S)-1-(2-hydroxy-4-methoxy-benzylcarbamoyl)-2-methyl-propyl]-amide 
• 376644-42-7 (2R,3R,4S)-4-tert-Butoxycarbonylamino-3-hydroxy-5-phenyl-2-(2,3,4-trimethoxy-benzylamino)-pentanoic acid 

Relevant articles and documents

Structure-based optimisation of 2-aminobenzylstatine derivatives: Potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome

We have identified 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the human 20S proteasome. A structure-based optimisation approach has allowed us to improve the potency of this structural class of proteasome inhibitors from micromolar to nanomolar level. The new derivatives showed good selectivity against the trypsin-like and post-glutamyl-peptide hydrolytic activities of this enzyme.