37753-64-3Relevant articles and documents
DIMETHYL ESTERS OF 1-AMINO-2-ARYLMETHYL CYCLOHEXYL PHOSPHONIC ACIDS. SYNTHESIS AND NMR CHARACTERIZATION
Failla, Salvatore,Finocchiaro, Paolo,Latronico, Mario
, p. 261 - 266 (2007/10/02)
Dimethyl esters of amino-arylmethyl phosphonic acids containing a cyclohexyl moiety have been prepared in good yields.All compounds are white crystalline powders very soluble in low boiling point organic solvents.Characterization by 1H-NMR techniques indicates that ortho substituents shift downfield the CH resonance, whereas ortho-carboxy groups, through hydrogen bonding with the NH group, yield a cyclic structure responsible of the dramatic downfield shift of the NH resonance.Key words: 1H-NMR characterization, crystalline, low-melting and very soluble amino-phosphonates, substrates for functionalization at the NH group.