37758-47-7

Basic information

• Product Name: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
• Synonyms: Ganglioside M1;GM1;GM1 Ganglioside (Brain, Ovine-SodiuM Salt);GM1 Ganglioside (Brain, Ovine-Sodium Salt);Monosialotetrahexosylganglioside Sodium;Ganglioside GM1 (Ovine Brain);Ganglioside GM?, Ammonium Salt, Bovine Brain;Sodium Monosialotetrahexosylganglioside Injection
• CAS NO: 37758-47-7
• Molecular Formula: C73H134N4O31
• Molecular Weight: 1563.85
• EINECS: 200-081-4
• Mol File: 37758-47-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1527 °C at 760 mmHg
• Flash Point: 877.3 °C
• Appearance: /lyophilized powder
• Density: 1.35 g/cm³
• Storage Temp.: −20°C
• Solubility: chloroform/methanol (9:1): 10 mg/mL, clear, colorless
• Water Solubility: soluble in chloroform/methanol (9:1): 10 mg/mL
• Merck: 14,4364
• CAS DataBase Reference: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(CAS DataBase Reference)
• NIST Chemistry Reference: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(37758-47-7)
• EPA Substance Registry System: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(37758-47-7)

Safety Data

• Statements: R22;R24/25:
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: FK1200000
• F: 10-21
• Hazardous Substances Data: 37758-47-7(Hazardous Substances Data)

Usage

Description

Ganglioside GM1, Ammonium Salt, Bovine is an acidic glycosphingolipid derived from the bovine brain. It is also known as brain ganglioside and is characterized by the presence of N-acetylneuraminic acid or N-glycolylneuraminic acid residues. GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE is upregulated in the developing brain and consists of five glycosyl units. Ganglioside GM1, Ammonium Salt, Bovine is an off-white powder and is a sialotetraosylceramide with a branched pentasaccharide structure.

Uses

Used in Pharmaceutical and Biomedical Research:
Ganglioside GM1, Ammonium Salt, Bovine is used as a research tool for studying various biological processes and interactions. It is particularly useful in the investigation of neurological disorders and the development of potential therapeutic strategies.
Used in Liposome Preparation:
In the pharmaceutical industry, Ganglioside GM1, Ammonium Salt, Bovine is used as a component in the preparation of liposomes. It is utilized in the formulation of small unilamellar vesicles for fluorescence studies and circular dichroism studies with human wild type synuclein. These studies help in understanding the structural and functional aspects of proteins and their interactions with lipids.
Used in Mass Spectrometry Analysis:
Ganglioside GM1, Ammonium Salt, Bovine serves as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis. It is used to calibrate and validate the mass spectrometry techniques, ensuring accurate and reliable results in the identification and quantification of lipids in biological samples.
Used in Drug Delivery Systems:
Ganglioside GM1, Ammonium Salt, Bovine can be employed in the development of drug delivery systems, particularly for targeting the central nervous system. Its unique properties and interactions with biological membranes make it a promising candidate for enhancing the delivery and bioavailability of therapeutic agents.

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.