37772-85-3

Basic information

• Product Name: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester
• Synonyms: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester
• CAS NO: 37772-85-3
• Molecular Formula: C₆H₇NO₄
• Molecular Weight: 157.12408
• Mol File: 37772-85-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: >270 °C
• Boiling Point: 389.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.494±0.06 g/cm3(Predicted)
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester(37772-85-3)
• EPA Substance Registry System: 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester(37772-85-3)

Safety Data

• Hazardous Substances Data: 37772-85-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester" is a methyl ester of 2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrole-3-carboxylic acid. It is a member of the pyrrole family and is commonly used in organic synthesis and pharmaceutical research. 2,5-dihydro-4-hydroxy-2-oxo-1H-Pyrrole-3-carboxylic acid Methyl ester is known for its potential antioxidant and anti-inflammatory properties, making it a key ingredient in the development of new drugs and treatments for various diseases. Its methyl ester form allows for better solubility and stability, making it easier to work with in laboratory settings. Overall, this compound has versatile applications in both the research and pharmaceutical industries due to its unique chemical structure and potential therapeutic benefits.

Upstream product

• 83544-51-8 methyl hippurylmalonate 
• 105688-28-6 N-Acetyl-α-carbomethoxytetramic acid 
• 105688-25-3 2-(2-Acetylamino-acetyl)-malonic acid dimethyl ester 
• 313496-20-7 C₇H₁₁NO₅ 
• 67-56-1 methanol 
• 51925-56-5 ethyl 3-((2-ethoxy-2-oxoethyl)amino)-3-oxopropanoate 

Downstream Products

• 1005179-35-0 C₁₇H₂₀N₂O₃ 
• 37772-89-7 pyrrolidine-2,4-dione 

Relevant articles and documents

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Studies on the synthesis and bioactivities of 4-amino derivatives of tetramic acid

In order to study the potential bioactivities of 4-amino tetramic acid derivatives, the 4-amination products of pyrrolidine-2,4-diones (5) and 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylates (4) were prepared. The 4-amination of 5 took place in high yield when catalyzed by acetic acid, whereas the 4-amination of 4 was achieved through a 4-ethoxy intermediate, which was prepared by acidic etherification. Their herbicidal, fungicidal, insecticidal, and antitumor activities were tested. The bioassays showed that two of the compounds exhibited good herbicidal activity against dicot Arabidopsis thaliana at a concentration of 10 μg/mL, and one compound gave instinct fungicidal activity against Pythium sp. at a concentration of 2 μg/mL.

Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. S