377774-80-6

Basic information

• Product Name: 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid ethyl ester
• Synonyms: 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid ethyl ester
• CAS NO: 377774-80-6
• Molecular Weight: 272.344
• Mol File: 377774-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid ethyl ester(377774-80-6)
• EPA Substance Registry System: 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid ethyl ester(377774-80-6)

Safety Data

• Hazardous Substances Data: 377774-80-6(Hazardous Substances Data)

Upstream product

• 119-67-5 o-carboxybenzaldehyde 
• 34046-43-0 ethyl 2-formylbenzoate 
• 928-90-5 5-hexyl-1-ol 

Downstream Products

• 377774-83-9 2-((1E,3Z)-8-Hydroxy-octa-1,3-dienyl)-benzoic acid 
• 377774-81-7 2-((1E,3Z)-8-Hydroxy-octa-1,3-dienyl)-benzoic acid ethyl ester 
• 377774-82-8 2-((E)-8-Hydroxy-oct-1-en-3-ynyl)-benzoic acid 

Relevant articles and documents

Stereocontrolled synthesis of the diene and triene macrolactones of oximidines I and II: Organometallic coupling versus standard macrolactonization

(matrix presented) Stereocontrolled construction of the 12-membered diene and triene lactones 1, 2, and 3, characteristic of the antitumor agent oximidines I and II, are reported and were based on an intramolecular Castro-Stephens coupling for the construction of a cyclic enyne or dienyne followed by stereoselective reduction of the cyclic alkyne for introduction of the cis-olefin of the targets. A comparison of the effectiveness of this protocol is made with standard macrolactonization.