3778-76-5 Usage
Description
Todralazine hydrochloride is a pharmaceutical compound with vasodilating properties, primarily used as an antihypertensive agent. It functions by relaxing the smooth muscles in the walls of blood vessels, leading to a reduction in blood pressure.
Uses
Used in Pharmaceutical Industry:
Todralazine hydrochloride is used as an antihypertensive agent for the treatment of high blood pressure. It is particularly effective due to its vasodilating properties, which help to relax the smooth muscles in the walls of blood vessels, thus reducing blood pressure.
Used in Research Applications:
Todralazine hydrochloride is also used as a research compound for studying its effects on blood pressure regulation and vascular health. This helps in understanding the underlying mechanisms of hypertension and developing new therapeutic strategies for its management.
Originator
Prorazin,Teisan
Manufacturing Process
A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol
is cooled, under agitation to a temperature of -10°C. To the suspension is
added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in
150 ml of anhydrous ethanol and the reaction mass is agitated for about 2
hours, maintaining a temperature of -10°C. The temperature is then raised to
about 20°C and stirring is continued for 2 hours, whereupon heating is applied
and boiling is maintained for 15 min. After cooling, the separated 1-
hydrazinophthalazine hydrochloride is filtered and washed with anhydrous
ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a
temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a
boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water,
and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature
of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and
washed with anhydrous ethanol. 11.5 g of a raw product are obtained which
for the purpose of purification are dissolved in 15 ml of boiling water with an
addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1-
carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are
obtained.
Therapeutic Function
Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 3778-76-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,7 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3778-76:
(6*3)+(5*7)+(4*7)+(3*8)+(2*7)+(1*6)=125
125 % 10 = 5
So 3778-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H
