37791-41-6

Basic information

• Product Name: 5(4H)-Oxazolone, 4-ethylidene-2-phenyl-
• Synonyms: 5(4H)-Oxazolone,4-ethylidene-2-phenyl;4-ethylidene-2-phenyl-1,3-oxazol-5(4H)-one;2-phenyl-4-ethylidene-5(4H)-oxazolone;4-Aethyliden-2-phenyl-5(4H)-oxazolon;4-ethylidene-2-phenyl-5-oxazolone;4-ethylidene-2-phenyl-4H-oxazol-5-one;4-Aethyliden-2-phenyl-4H-oxazol-5-on
• CAS NO: 37791-41-6
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Mol File: 37791-41-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87-89 °C(Solv: ethanol (64-17-5))
• Boiling Point: 281.0±23.0 °C(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 5(4H)-Oxazolone, 4-ethylidene-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-ethylidene-2-phenyl-(37791-41-6)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-ethylidene-2-phenyl-(37791-41-6)

Safety Data

• Hazardous Substances Data: 37791-41-6(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 7469-23-0 N-benzoyl-DL-allothreonine 
• 108-24-7 acetic anhydride 
• 7469-23-0 N-benzoyl-DL-threonine 
• 98-88-4 benzoyl chloride 
• 1199-01-5 2-phenylazlactone 
• 75-07-0 acetaldehyde 
• 4411-93-2 2-ethylidene-4-oxo-4-phenylbutyric acid 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 495-69-2 Hippuric Acid 
• 93-97-0 benzoic acid anhydride 
• 7719-09-7 thionyl chloride 
• 857780-50-8 N-benzoylthreonine 

Downstream Products

• 131644-54-7 O-methyl-N-benzoyl-DL-threonine 
• 64419-93-8 (Z)-5-ethylidene-2-thioxoimidazolidin-4-one 
• 104296-32-4 (+/-)-N-(5c-methyl-3-oxo-isoxazolidin-4r-yl)-benzamide 
• 874525-71-0 3-ethoxycarbonylmethylsulfanyl-2-benzoylamino-butyric acid ethyl ester 
• 99973-53-2 4-(1-chloro-ethylidene)-2-phenyl-4H-oxazol-5-one 
• 112575-30-1 4-(1-bromo-ethylidene)-2-phenyl-4H-oxazol-5-one 
• 99852-60-5 4-chloro-4-(1-chloro-ethyl)-2-phenyl-4H-oxazol-5-one 
• 4411-93-2 2-ethylidene-4-oxo-4-phenylbutyric acid 
• 5468-52-0 N-benzoyl-2-aminobutyric acid 
• 103862-68-6 2-benzoylamino-3-chloro-crotonic acid 
• 1373956-93-4 4-ethylidene-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one 
• 71953-25-8 4-(1-methyl-pentyl)-4-(3-oxo-3-phenyl-cis-propenyl)-2-phenyl-4H-oxazol-5-one 
• 71953-41-8 5-Methyl-1-phenyl-1,4-nonandion 
• 4491-48-9 1,1-dimethyl-5-phenyl-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene 

Relevant articles and documents

Synthesis, in-vitroreverse transcriptase inhibitory activity and docking study of some new imidazol-5-one analogs

Non-nucleoside reverse transcriptase inhibitors have a definitive role and most commonly used in treatment of HIV-1 infection. A new series of 4-ethylidene/substituted-benzylidene-1-(4-hydroxy/chloro-6-methylpyrimidin-2-yl) -2-ethyl/phenyl-1H-imidazol-5(4H)-one were designed, synthesized, and evaluated for HIV-1 reverse transcriptase (RT) inhibitory activity. The results of in-vitro HIV-1 RT assay showed that some of the new compounds, such as 4c, 4d, 4e, 5a, and 5e effectively inhibit HIV-1 RT activity. 1-(4-Chloro-6- methylpyrimidin-2-yl)-4-(furan-2-ylmethylene)-2-methyl-1H-imidazol-5(4H)-one (5e) exerted most potent in-vitro HIV-1 RT inhibitory activity, among the group of compounds. Molecular docking studies were carried out to explore the binding affinity of imidazole-5-one analogs in active site of HIV-1 RT enzyme. Springer Science+Business Media 2014.

Thionation of N-acylthreonine and its methyl ester with Lawesson's reagent: Synthesis of 5-oxazolones, 5-thiazolones and thiazolines

The treatment of N-acylthreonine (1) with Lawesson's reagent [LR: 2,4-bis(p-methoxyphenyl)-1,3,2,4-dithiaphosphetane 2,4-disulfide] afforded 5-oxazolones (2) in moderate yields, along with 5-thiazolones (3). On the other hand, N- acylthreonine methyl este