37800-98-9 Usage
Description
1H-Imidazole-4-carboxamide,5-amino-2-methyl-(9CI), also known as amiloride, is a chemical compound with the molecular formula C6H8N4O. It is a white crystalline solid that is soluble in water and has a molecular weight of 156.15 g/mol. Amiloride is commonly used as a diuretic and works by inhibiting the sodium-hydrogen ion exchange in the distal convoluted tubule of the kidneys, leading to increased excretion of sodium and water, and decreased excretion of potassium.
Uses
Used in Pharmaceutical Industry:
1H-Imidazole-4-carboxamide,5-amino-2-methyl-(9CI) is used as a diuretic for the treatment of conditions such as hypertension, heart failure, and edema. It helps in reducing the volume of extracellular fluid and lowering blood pressure by promoting the excretion of sodium and water from the body.
Used in Nephrology:
Amiloride is used in the prevention of kidney stones, particularly those composed of calcium oxalate. It has been shown to reduce the concentration of calcium and oxalate in the urine, thereby decreasing the risk of stone formation.
Used in Pulmonology:
Amiloride has been studied for its potential use in treating conditions such as cystic fibrosis. It has been found to reduce the viscosity of mucus in the airways, making it easier to clear and improving lung function.
However, it is important to note that amiloride also has potential side effects, including hyperkalemia and acidosis, and it should be used with caution in patients with impaired renal function.
Check Digit Verification of cas no
The CAS Registry Mumber 37800-98-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,8,0 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 37800-98:
(7*3)+(6*7)+(5*8)+(4*0)+(3*0)+(2*9)+(1*8)=129
129 % 10 = 9
So 37800-98-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H8N4O/c1-2-8-3(5(7)10)4(6)9-2/h6H2,1H3,(H2,7,10)(H,8,9)
