37847-52-2

Basic information

• Product Name: 2,4-Difluorobiphenyl
• Synonyms: 2,4-difluoro-1,1'-biphenyl;2,4-DIFLUOROPHENYLBENZENE;2,4-DIFLUOROBIPHENYL;2,4-difluorobiphene;2,4-Difluorodiphenyl;DIFLUOROBIPHENYL;1,1'-Biphenyl,2,4-difluoro-;2,4 Difluoro-1,1'-biphenyl≥ 99% (GC)
• CAS NO: 37847-52-2
• Molecular Formula: C₁₂H₈F₂
• Molecular Weight: 190.19
• EINECS: 253-690-2
• Product Categories: Biphenyl derivatives;Biphenyl & Diphenyl ether
• Mol File: 37847-52-2.mol
• Article Data: 31

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 243.7 °C at 760 mmHg
• Flash Point: 83 °C
• Appearance: White crystal
• Density: 1.165 g/cm³
• Vapor Pressure: 17.5mmHg at 25°C
• Refractive Index: 1.377
• Storage Temp.: 2-8°C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: 2,4-Difluorobiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorobiphenyl(37847-52-2)
• EPA Substance Registry System: 2,4-Difluorobiphenyl(37847-52-2)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-50/53-41-37/38-22
• Safety Statements: 20/21-24/25-61-60-39-26
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HazardClass: 9
• PackingGroup: II
• Hazardous Substances Data: 37847-52-2(Hazardous Substances Data)

Usage

Description

2,4-Difluorobiphenyl is an organic compound characterized by its white crystalline structure. It is a type of biphenyl, which is a derivative of benzene, with two fluorine atoms attached to the 2nd and 4th carbon atoms of the molecule. 2,4-Difluorobiphenyl is known for its unique chemical properties and potential applications in various industries.

Uses

Used in the Chemical Industry:
2,4-Difluorobiphenyl is used as a key intermediate in the synthesis of various organic compounds and materials. Its unique structure and chemical properties make it a valuable building block for creating new molecules with specific characteristics and functions.
Used in the Pharmaceutical Industry:
2,4-Difluorobiphenyl is used as a starting material for the development of pharmaceutical compounds. Its specific chemical structure can be modified to create new drugs with potential therapeutic applications.
Used in the Electronics Industry:
2,4-Difluorobiphenyl is used in the preparation of blue light-excitable orange-red cationic iridium(III) complex for LED (Light Emitting Diode) applications. Its unique optical properties make it suitable for use in the development of advanced lighting technologies.
Used in the Research and Development Sector:
2,4-Difluorobiphenyl serves as a valuable compound for research purposes, allowing scientists to study its properties and explore its potential applications in various fields, including materials science, chemistry, and biology.

InChI:InChI=1/C4H3BrF4O2/c1-11-2(10)3(5,6)4(7,8)9/h1H3

Upstream product

• 96227-76-8 (2,4-Difluoro-phenyl)-piperidin-1-yl-diazene 
• 71-43-2 benzene 
• 372-18-9 1,3-Difluorobenzene 
• 94-36-0 dibenzoyl peroxide 
• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 
• 884844-86-4 2-phenyl-4-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-henicosafluorodecyl)-[1,3,2]dioxaborolane 
• 348-57-2 2,4-difluorobromobenzene 
• 98-80-6 phenylboronic acid 
• 367-25-9 2,4-difluorophenylamine 
• 40594-30-7 2,4-difluorophenylhydrazine 
• 149-73-5 trimethyl orthoformate 
• 75-36-5 acetyl chloride 
• 110-46-3 isopentyl nitrite 
• 943611-16-3 1-{6-[dibutyl(phenyl)stannyl]hexyl}-3-methyl-1H-imidazolium iodide 

Downstream Products

• 112344-52-2 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid 
• 161692-81-5 4-(2',4'-difluorobiphenyl-4-yl)-2-methylene-4-oxobutanoic acid 
• 53591-79-0 1-(2',4'difluoro[1,1']biphenyl-4-yl)ethanone 
• 59089-67-7 4-(2,4-difluorophenyl)phenyl acetate 
• 170950-55-7 5-(2',4'-Difluoro-biphenyl-4-yl)-5-hydroxy-4-methyl-5H-furan-2-one 
• 59089-68-8 4-(2,4-difluorophenyl)-phenol 
• 477860-13-2 2-fluoro-4-hydroxy-[1,1'-biphenyl] 
• 92-52-4 biphenyl 
• 942475-01-6 2′,4′-difluoro-biphenyl-4-sulfonylchloride 

Relevant articles and documents

Pd nanoparticles in silica hollow spheres with mesoporous walls: A nanoreactor with extremely high activity

A true nanoreactor composed of mesoporous silica hollow spheres and Pd nanoparticles residing inside the spheres shows superior activity in Suzuki coupling reactions with 99.5% yield in 3 min.

An efficient heterogeneous Pd catalyst for the Suzuki coupling: Pd/Al 2O3

PdII-loading alumina catalyst, which is simply prepared through impregnation of γ-alumina with Pd(OAc)2 followed by calcination in the air, shows a high catalytic activity for the Suzuki coupling of aryl bromides with arylboronic acids under phosphine ligand-free conditions. Only 0.25 mol% of palladium is sufficient for the promotion of the couplings in ethanol. Copyright

Method for synthesizing biphenyl compounds by adopting microchannel reactor

The invention relates to a method for synthesizing biphenyl compounds by adopting a microchannel reactor. The method comprises the following steps: mixing a compound shown in a formula (1), a compound shown in a formula (2), a compound shown in a formula (3) and a copper catalyst in the microchannel reactor, carrying out diazotization coupling reaction, and purifying the obtained reaction product to obtain a compound shown in a formula (4). Compared with the prior art, the micro-channel reactor is adopted, so that the diazotization coupling reaction time is effectively shortened, the reaction stability and efficiency are improved, the reaction yield and purity are improved, and the method has the advantages of environmental protection, safety, simple process, low cost, continuous industrial production and the like.

Recombinant Peptide Fusion Protein-Templated Palladium Nanoparticles for Suzuki-Miyaura and Stille Coupling Reactions

This study examined the use of nanoparticles created with recombinant 45-amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki-Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb) and could be recycled. This study establishes a potentially cost-effective approach to prepare heterogeneous catalysts containing well-defined nanoparticles enabling key C?C bond formation leading to synthetically and pharmaceutically interesting compounds.