37857-30-0Relevant articles and documents
A palladium-catalyst stabilized in the chiral environment of a monoclonal antibody in water
Kobayashi, Yuichiro,Murata, Keisuke,Harada, Akira,Yamaguchi, Hiroyasu
supporting information, p. 1605 - 1607 (2020/02/13)
We report the first preparation of a monoclonal antibody (mAb) that can immobilize a palladium (Pd)-complex. The allylic amination reaction using a supramolecular catalyst consisting of the Pd-complex and mAb selectively gives the (R)-enantiomer product w
Domino reaction of a gold catalyzed 5-: Endo-dig cyclization and a [3,3]-sigmatropic rearrangement towards polysubstituted pyrazoles
Verlee, Arno,Heugebaert, Thomas,Van Der Meer, Tom,Kerchev, Pavel,Van Breusegem, Frank,Stevens, Christian V.
supporting information, p. 9359 - 9363 (2019/01/03)
Pyrazoles are important heterocyclic compounds with a broad range of biological activities. A new procedure toward tri- or tetrasubstituted pyrazoles has been developed, via a one-pot gold catalyzed synthesis from hydrazines with alkynyl aldehydes or keto
One-Pot Three-Component Synthesis of Vicinal Diamines via In Situ Aminal Formation and Carboamination
Orcel, Ugo,Waser, Jerome
supporting information, p. 12881 - 12885 (2016/10/04)
A synthesis of vicinal diamines via in situ aminal formation and carboamination of allyl amines is reported. Employing highly electron-poor trifluoromethyl aldimines in their stable hemiaminal form was key to enable both a fast and complete aminal formation as well as the palladium-catalyzed carboamination step. The conditions developed allow the introduction of a wide variety of alkynyl, vinyl, aryl, and hetereoaryl groups with complete regioselectivity and high diastereoselectivity. The reaction exhibits a high functional-group tolerance. Importantly, either nitrogen atom of the imidazolidine products can be selectively deprotected, while removal of the aminal tether can be achieved in a single step under mild conditions to reveal the free diamine. We expect that this work will promote the further use of mixed aminal tethers in organic synthesis.
