37893-28-0

Basic information

• Product Name: 1H-Pyrrole-2,5-dicarboxaldehyde, 1-methyl-
• Synonyms: 1H-Pyrrole-2,5-dicarboxaldehyde,1-methyl;N-methylpyrrole-2,5-dicarboxaldehyde;1-methyl-pyrrole-2,5-dicarbaldehyde;1-methylpyrrole-2,5-dicarboxaldehyde
• CAS NO: 37893-28-0
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.13600
• Mol File: 37893-28-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dicarboxaldehyde, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dicarboxaldehyde, 1-methyl-(37893-28-0)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dicarboxaldehyde, 1-methyl-(37893-28-0)

Safety Data

• Hazardous Substances Data: 37893-28-0(Hazardous Substances Data)

Upstream product

• 81697-87-2 2-(5,5-dimethyl-1,3-dioxan-2-yl)-1-methyl-1H-pyrrole 
• 96-54-8 N-Methylpyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 39604-60-9 pyrrole-2,5-biscarboxaldehyde 
• 74-88-4 methyl iodide 
• 153850-73-8 2,5-bis(1,3-benzodithiol-2-yl)-1-methylpyrrole 
• 81697-94-1 1-methyl-5-(5,5-dimethyl-1,3-dioxan-2-yl)-1H-pyrrole-2-carbaldehyde 
• 1192-58-1 N-methylpyrrole aldehyde 
• 58488-39-4 2,5-bis(1,3-benzodithiol-2-yl)pyrrole 

Downstream Products

• 1421709-23-0 C₁₉H₁₇N₃ 

Relevant articles and documents

1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

A Convenient General Method for the Synthesis of Pyrrole-2,5-dicarbaldehydes

A new general method for the synthesis of pyrrole-2,5-dicarbaldehyde and its 3-mono- and 3,4-disubstituted derivatives is reported.It involves the intermediate formation of the corresponding 2,5-bis(1,3-benzodithiol-2-yl)pyrroles followed by hydrolysis with HgO-35percent aq.HBF4-DMSO.Pyrrole-2,5-dicarbaldehyde was obtained in overall yields of 43-65percent, whilst that of the derivatives was 32-90percent.Moreover the methylation of the corresponding dithiolic intermediate with further hydrolysis resulted in the formation of 1-methylpyrrole-2,5-dicarbaldehyde in 90percent overall yield.

PYRROLE CHEMISTRY. XXIV. THE VILSMEIER FORMYLATION AND CYANATION OF PYRROLE ACETALS. A SYNTHESIS OF PYRROLE-2,3,5-TRICARBOXALDEHYDE

The preparation of the acetals of a number of pyrrole mono- and dicarboxaldehydes is described.It is shown that, provided the reactivity of the unsubstituted ring positions on the pyrrole nucleus is not too low, a carboxaldehyde or a carbonitrile group may be substituted on the pyrrole ring using the Vilsmeier reaction or chlorosulfonyl isocyanate respectively. Vilsmeier formylation of the diacetal, 2,4-di(5,5-dimethyl-1,3-dioxan-2-yl)-pyrrole, followed by hydrolysis gave pyrrole-2,3,5-tricarboxaldehyde.