37905-08-1Relevant articles and documents
A 17 - hydroxy - crag root of beijing euphorbia lactone B synthetic method of
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Paragraph 0038-0039; 0059, (2018/05/16)
The invention provides a semisynthesis method of 17-hydroxyjolkinolide B. The semisynthesis method comprises the following steps: carrying out a cyclization reaction on a double bond at the C11 position of an epoxy ring of Jolkinolide A serving as a raw material; bromizing a methyl at the C17 position of a lactonic ring, then carrying out debromination and acetylation, and finally hydrolyzing an acetyl to obtain 17-hydroxyjolkinolide B. The invention discloses a new method for synthesizing 17-hydroxyjolkinolide B and provides a basis for research and development of jolkinolide type medicines. The successful synthesis of 17-hydroxyjolkinolide B provides a new direction for research of anti-cancer drugs. The method has the advantages that the yield of 17-hydroxyjolkinolide B can be improved, the production cost can be reduced, the market supply is enlarged and the cancer treatment cost is lowered.
Efficient Synthesis of Jolkinolides A and B from Steviol
Zhu, Chang-Zhen,Wang, Ke,Zhang, Meng-Han,Zhang, Da-Yong,Wu, Yang-Chang,Wu, Xiao-Ming,Hua, Wei-Yi
, p. 2574 - 2578 (2015/12/26)
Jolkinolides, isolated from Euphorbia fischeriana Steud, are naturally occurring tetracyclic ent-abietane diterpenes, some of which exhibit promising antitumor and other biological activity. An efficient strategy for the synthesis of jolkinolides A and B is described starting from readily available steviol in 10 and 11 steps with total yields of over 10%, respectively.
Total Synthesis of (+/-)-Jolkinolide A and B
Katsumura, Shigeo,Kimura, Akihiko,Isoe, Sachihiko
, p. 330 - 331 (2007/10/02)
The first efficient synthesis of jolkinolide A and B from the diosphenol (7) is reported; the new synthetic method described may find use in the preparations of 4-ylidene-2,3-substituted butenolides.
