379261-85-5

Basic information

• Product Name: Benzoic acid, 3-(1-methylethoxy)-4-nitro-
• CAS NO: 379261-85-5
• Molecular Formula: C10H11NO5
• Molecular Weight: 225.201
• Mol File: 379261-85-5.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-(1-methylethoxy)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-(1-methylethoxy)-4-nitro-(379261-85-5)
• EPA Substance Registry System: Benzoic acid, 3-(1-methylethoxy)-4-nitro-(379261-85-5)

Safety Data

• Hazardous Substances Data: 379261-85-5(Hazardous Substances Data)

Upstream product

• 619-14-7 3-hydroxy-4-nitro-benzoic acid 
• 713-52-0 methyl 3-hydroxy-4-nitrobenzoate 
• 403-21-4 3-fluoro-4-nitrobenzoic acid 
• 67-63-0 isopropyl alcohol 
• 159783-41-2 methyl 3-isopropyloxy-4-nitrobenzoate 
• 75-26-3 isopropyl bromide 

Downstream Products

• 1006031-13-5 methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-nitro-benzoylamino)-benzoylamino)-benzoate 
• 1006030-98-3 methyl 3-propoxy-4-(3-benzyloxy-4-(3-isopropyloxy-4-nitro-benzoylamino)-benzoylamino)-benzoate 
• 1006031-06-6 C₄₁H₄₆N₄O₁₁ 
• 1006031-11-3 C₅₁H₅₇N₅O₁₃ 
• 1006031-12-4 C₆₃H₅₉N₅O₁₃ 
• 1006030-83-6 methyl 3-isopropoxy-4-(3-isopropoxy-4-nitro-benzoylamino)-benzoate 
• 1147135-00-9 C₁₉H₂₈N₂O₆ 
• 1201694-14-5 3-isopropoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide 
• 1318208-92-2 isopropyl 3-isopropoxy-4-(3-isopropoxy-4-nitrobenzamido)benzoate 
• 1373319-43-7 methyl 3-isopropoxy-4-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)benzoate 
• 1006030-92-7 methyl 3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoate 
• 1006031-03-3 methyl 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamino)-benzoylamino)-benzoate 
• 1190360-14-5 3-isopropoxy-4-(3-isopropoxy-4-(3-isopropoxy-4-amino-benzoylamido)-benzoylamido)-benzoic acid 
• 1373319-41-5 methyl 3-isopropoxy-4-(3-isopropoxy-4-(6-isopropoxy-5-nitropicolinamido)benzamido)benzoate 

Relevant articles and documents

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics

Lack of new antibiotics and increasing antimicrobial resistance are among the main concerns of healthcare communities nowadays, and these concerns necessitate the search for novel antibacterial agents. Recently, we discovered the cystobactamids—a novel natural class of antibiotics with broad-spectrum antibacterial activity. In this work, we describe 1) a concise total synthesis of cystobactamid 507, 2) the identification of the bioactive conformation using noncovalently bonded rigid analogues, and 3) the first structure–activity relationship (SAR) study for cystobactamid 507 leading to new analogues with high metabolic stability, superior topoisomerase IIA inhibition, antibacterial activity and, importantly, stability toward the resistant factor AlbD. Deeper insight into the mode of action revealed that the cystobactamids employ DNA minor-groove binding as part of the drug–target interaction without showing significant intercalation. By designing a new analogue of cystobactamid 919-2, we finally demonstrated that these findings could be further exploited to obtain more potent hexapeptides against Gram-negative bacteria.

NOVEL CYSTOBACTAMIDE DERIVATIVES

The present invention relates to novel derivatives of cystobactamides of formula (lb) and the use thereof for the treatment or prophylaxis of bacterial infections.

A structure—activity relationship study of bis-benzamides as inhibitors of androgen receptor—coactivator interaction

The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of the