379268-07-2

Basic information

• Product Name: 3-(4-(tert-butyl)phenyl)isoxazol-5(4H)-one
• Synonyms: 3-(4-(tert-butyl)phenyl)isoxazol-5(4H)-one
• CAS NO: 379268-07-2
• Molecular Weight: 217.268
• Mol File: 379268-07-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-(tert-butyl)phenyl)isoxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(tert-butyl)phenyl)isoxazol-5(4H)-one(379268-07-2)
• EPA Substance Registry System: 3-(4-(tert-butyl)phenyl)isoxazol-5(4H)-one(379268-07-2)

Safety Data

• Hazardous Substances Data: 379268-07-2(Hazardous Substances Data)

Upstream product

• 200280-57-5 methyl 3-(4-(tert-butyl)phenyl)-3-oxopropanoate 
• 943-27-1 4'-t-butylacetophenone 
• 616-38-6 carbonic acid dimethyl ester 
• 101498-88-8 3-(4-tert-butylphenyl)-3-oxopropionic acid ethyl ester 

Downstream Products

• 1353036-81-3 3-(4-tert-butylphenyl)-4-(5-methylthienylmethylene)isoxazol-5(4H)-one 

Relevant articles and documents

Palladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high atomic economy due to no elimination of CO2 occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies. (Figure presented.).

Palladium catalyzed insertion reaction of isocyanides with 3-arylisoxazol-5(4 H)-ones: Synthesis of 4-aminomethylidene isoxazolone derivates

A palladium catalyzed insert reaction of isocyanides to 3-arylisoxazol-5(4H)-ones for the construction of 4-aminomethylidene isoxazolone derivates is reported. In this transformation, only the C-H bond of the methylene group was involved while the remaining ring structure was retained. In general, this work provided a new protocol for the synthesis of 4-aminomethylidene isoxazolones.