37941-52-9

Basic information

• Product Name: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, methyl ester
• CAS NO: 37941-52-9
• Molecular Formula: C17H20N4O5
• Molecular Weight: 360.37
• Mol File: 37941-52-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, methyl ester(37941-52-9)
• EPA Substance Registry System: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-, methyl ester(37941-52-9)

Safety Data

• Hazardous Substances Data: 37941-52-9(Hazardous Substances Data)

Upstream product

• 1738-86-9 Z-Gly-ONp 
• 7389-87-9 L-histidine methyl ester dihydrochloride 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 4816-85-7 Z-Gly carbamoylmethyl ester 
• 4467-54-3 histidine methyl ester hydrochloride 
• 4467-54-3 l-histidine methyl ester dihydrochloride 

Downstream Products

• 38972-84-8 N^α-(N-benzyloxycarbonyl-glycyl)-histidine 
• 15266-88-3 Cyclo(glycyl-L-histidyl) 

Relevant articles and documents

Co-ordination Properties of Cyclopeptides. Formation and Stability of Zinc(II) and Copper(II) Complexes of Histidine-containing Cyclopeptides, or Imidazole

In order to obtain an improved understanding of the complexing properties of cyclopeptides involved in biological processes, the interaction of zinc(II) with cyclo(L-histidyl-L-histidyl) was studied by potentiometric and calorimetric techniques in aqueous solution.Comparison between the thermodynamic parameters of the complexes formed with those for analogous species formed with cyclo(glycyl-L-histidyl) allowed evidence to be obtained for the formation of chelate rings of unusual size.The thermodynamic quantities associated with copper(II) complex formation with cyclo(-Gly-His-) were determined.The role of the different stereochemical requirements of copper(II) and zinc(II) in the formation of large chelate rings was assessed by means of previously reported data concerning the copper(II)-cyclo(-His-His-) complexes.

Protease-catalysed synthesis of peptides containing histidine and lysine

The kinetically controlled α-chymotrypsin- and trypsin-catalysed syntheses of peptides starting from simple acyl donor esters containing histidine at the P1-position (nomenclature according to Schechter and Berger) and lysine derivatives as amino components were examined on the basis of their kinetic parameters. Despite higher specificity constants (k(cat)/K(M)) of trypsin-catalysed ester hydrolysis, α-chymotrypsin- catalysed acyl transfer to N(ε)unprotected lysine derivatives gave higher peptide yields as compared to trypsin-catalysed reactions, whereas in acyl transfer to N(ε)-protected lysine derivatives the trypsin-catalysed reaction gave higher yields. α-Chymotrypsin-catalysed acyl transfer reactions in frozen systems demonstrated the yield-enhancing effect of freezing. Using specific ester leaving groups, both the amount of enzyme and the reaction time can be reduced. In frozen systems the ε-amino function of H-Lys-OH acts as an acyl acceptor at pH ≤9.

Acid dissociation constants of some histidine containing peptides and formation constants of their metal complexes

-